Overview
Healing by fibrosis, instead of regeneration, causes a huge problem in public health. Current knowledge of the mechanisms that control scar formation is insufficient. Thus, the study that aims to recognize the mechanisms that control reparative wound healing process (scar-forming) in order to re-activate regenerative pathway are one of the most important in medicine.
In our study we focus on the role of transcriptional factor, Foxn1, whose expression is limited to the skin and thymus in mice and humans. We showed that Foxn1 deficient (nude) mice are unique among adult mammals in their ability to regenerate, heal skin injuries in scar-free way. The main goal of our present study is to:
- explore the contribution and the role of transcription factor Foxn1 in skin physiology;
- better understand how Foxn1, that is expressed in epidermis and hair follicles, affects skin functionality, wound healing, dWAT organization and post wounding reestablishment of the skin in the context of age, diet and oxygen availability;
- apply adipose derived stem cells (ASCs) isolated from subcutaneous fat of domestic pigs (pASCs) as a candidates of possible therapeutic potential to improve wound healing (translational study).
Contact
Institute of Animal Reproduction and Food Research
Polish Academy of Sciences in Olsztyn
Tuwima 10
10-748 Olsztyn
+48 89 523 46 34
+48 89 523 46 37
