EN

Current projects C&BoF

  1. Promoting Innovation of ferMENTed fOods (PIMENTO), COST Action CA20128 (2021-2025).
  2. Reducing acrylamide exposure of consumers by a cereals supply-chain approach targeting asparagine (ACRYRED), CA21149 (2022-2026).
  3. KETO-MINOX: The effect of isocaloric, energy-restrictive, KETOgenic diet on Metabolism, Inflammation, Nutrition deficiencies and OXidative stress in women with overweight and obesity. NCN OPUS 21 (2022-2025).
  4. Effect of intestinal microbiota modulation induced by the chicory inulin-type β-fructans on metabolic parameters and biomarkers of the gut-skin axis in chronic skin inflammation. NCN OPUS 25 (2023-2026).
  5. Development of innovative fruit and vegetable preserves that maintain the optimal and beneficial composition of health-promoting substances with the use of unique types of carrots and strawberries. (ARiMR, 2019-2023).
  6. Implementation doctorate „Study of the degradation and absorption processes of anthocyanins from the newly developed models of food products in the context of their health-promoting properties”. (MNiSW, 2020-2024).
  7. Concentrated juice from red-flesh apples as an innovative application for products with increased pro-health properties produced under the Tymbark brand. (ARiMR, 2019-2023).
  8. B+R research on the development of products dedicated to seniors. Project number: RUI/04/12/2019 (TYMBARK-MWS Sp. z o.o. Sp.k.) (2020-2023).
  9. Towards coordinated microbiome R&I activities in the food system to support (EU and) international bioeconomy goals”, Microbiome 2018-2022 (EU).
  10. SOURDOugh biotechnology network towards novel, healthier and sustainable food and bIoproCesseS (SOURDOmICS), COST Action (2019-2023).
  11. Optimization of bakery processes by a computational tool together with consumer feedback to minimize ecological footprint and food waste. (EIT Food, 2020-2022).
  12. Post-harvest School. Numer projektu: EIT Food 21304 (2022).

Read more

Equipment and applied methods PoMD

Equipment

  1. NanoDrop 2000 – Micro-Volume UV-Vis Spectrophotometer for Nucleic Acid and Protein Quantitation
  2. Centrifuge Eppendorf 5430R Eppendorf
  3. Thermo Stat Plus Eppendorf
  4. BioScan 920-2 Maltron – body composition analyzer
  5. US AutoFlow  CO2 Water-Jacketed Incubator NU-4950E
  6. CellGard ES NU-480 Class II, Type A2 Biosafety Cabinet
  7. OLYMPUS  IX51 inverted microscope combinations of fluorescence microscopy with additional contrast-enhancing techniques using both phase contrast and differential interference contrast (DIC) methods
  8. Laboratory water bath with agitation B5-11
  9. Trans-Blot Turbo Transfer System, high-performance western blotting transfer system designed to provide rapid transfers with high efficiency
  10. Mini-PROTEAN Tetra cell for 1-D vertical gel electrophoresis, make running protein or DNA on polyacrylamide gels

Methods applied

  1. Euglycemic hyperinsulinemic clamp
  2. Indirect calorimetry
  3. Assessment of body composition with bioelectric impedance analysis
  4. Measurement of serum concentrations of selected proteins with ELISA
  5. Biopsy of vastus lateralis muscle
  6. Biopsy of subcutaneous abdominal adipose tissue
  7. Isolation of peripheral blond mononuclear cells
  8. Analysis of tissue gene expression with RT-PCR
  9. Analysis of tissue protein content with Western blot
  10. Human muscle cell cultures

Read more

Publications PoMD

2026

  1. Danowska, Magdalena orcid; Nikołajuk, Agnieszka orcid; Strączkowski, Marek orcid. Skeletal muscle expression of the genes associated with glycoprotein 130 signaling in relation to obesity and insulin sensitivity. Journal of Endocrinological Investigation 2026, przyjęta do druku (10.1007/s40618-025-02781-4).

2025

  1. Aleksandrowicz, Róża orcid; Strączkowski, Marek orcid. RXRs expression in skeletal muscle in relationship with insulin sensitivity in normal-weight and obese volunteers. Journal of Diabetes and Metabolic Disorders 2025, 24(1): art. no 51 (1-6) (10.1007/s40200-024-01546-9).

2024

  1. Danowska, Magdalena orcid; Stefanowicz, Magdalena; Strączkowski, Marek orcid. The expression of NFAT family genes in subcutaneous adipose tissue before and after weight loss in obese individuals. Nutrition, Metabolism and Cardiovascular Diseases 2024, 34(11): 2455-2463 (10.1016/j.numecd.2024.06.011).

  2. Karczewska-Kupczewska, Monika; Stefanowicz, Magdalena; Nikołajuk, Agnieszka orcid; Strączkowski, Marek orcid. Weight-reducing dietary intervention increases the ability of hyperinsulinemia to suppress serum ghrelin concentration in individuals with obesity. Journal of Nutrition 2024, 154(5): 1631-1639 (10.1016/j.tjnut.2023.12.043).

  3. Karczewska-Kupczewska, Monika; Stefanowicz, Magdalena; Nikołajuk, Agnieszka orcid; Strączkowski, Marek orcid. Association of skeletal muscle karyopherin α1 and α2 with myogenesis and insulin action. Polish Archives of Internal Medicine – Polskie Archiwum Medycyny Wewnętrznej 2024, 134(7-8): art. no 16797 (1-5) (10.20452/pamw.16797).

  4. Klejbuk, Kamil orcid; Strączkowski, Marek orcid. Interleukin-38 and Insulin Resistance. Endocrine, Metabolic and Immune Disorders – Drug Targets 2024, 24(6): 611-616 (10.2174/1871530323666230911114150).

  5. Klejbuk, Kamil orcid; Strączkowski, Marek orcid. Impact of weight loss on the expression of negative regulators of nuclear factor κB (NLRP12, NLRC3, and NLRX1) in subcutaneous adipose tissue. Polish Archives of Internal Medicine – Polskie Archiwum Medycyny Wewnętrznej 2024, 134(4): art. no 16721 (1-4) (10.20452/pamw.16721).

  6. Strączkowski, Marek orcid; Stefanowicz, Magdalena, Nikołajuk, Agnieszka; Karczewska-Kupczewska, Monika. The effect of diet-induced weight-loss on subcutaneous adipose tissue expression of genes associated with thyroid hormone action. Clinical Nutrition 2024, 43(12): 245-250 (10.1016/j.clnu.2024.11.006).

2023

  1. Aleksandrowicz, Róża; Stefanowicz, Magdalena; Strączkowski, Marek. Skeletal muscle integrin expression in non-obese men with varying degrees of insulin sensitivity. Endocrine Journal 2023, 70(9): 909-915 (10.1507/endocrj.EJ23-0151).
  2. Aleksandrowicz, Róża; Strączkowski, Marek. Link between insulin resistance and skeletal muscle extracellular matrix remodeling. Endocrine Connections 2023, 12(5): art. no e230023 (1-12) (10.1530/EC-23-0023).
  3. Danowska, Magdalena; Strączkowski, Marek. The Ca 2+/Calmodulin-dependent Calcineurin/NFAT Signaling Pathway in the Pathogenesis of Insulin Resistance in Skeletal Muscle. Experimental and Clinical Endocrinology and Diabetes 2023, 131(11): 589-594 (10.1055/a-2174-7958).
  4. Nikołajuk, Agnieszka; Stefanowicz, Magdalena; Strączkowski, Marek; Karczewska-Kupczewska, Monika. Changes in adipose tissue gene expression of the core components of the Hippo signaling pathway in young adults with uncomplicated overweight or obesity following weight loss. Journal of Nutrition 2023, 153(3): 665-672 (10.1016/j.tjnut.2023.01.024).
  5. Strączkowski, Marek; Stefanowicz, Magdalena; Nikołajuk, Agnieszka; Karczewska-Kupczewska, Monika. Subcutaneous adipose tissue circadian gene expression: Relationship with insulin sensitivity, obesity, and the effect of weight-reducing dietary intervention. Nutrition 2023, 115: art. no 112153 (1-6) (10.1016/j.nut.2023.112153).
  6. Strączkowski, Marek; Stefanowicz, Magdalena; Nikołajuk, Agnieszka; Karczewska-Kupczewska, Monika. Subcutaneous adipose tissue expression of genes associated with glucocorticoid action: relationship with insulin sensitivity, obesity, and weight loss. Polish Archives of Internal Medicine-Polskie Archiwum Medycyny Wewnetrznej 2023, 133(12): art. no 16621 (1-5) (10.20452/pamw.16621).

2022

  1. Dobrzycka, Marta; Kołakowski, Adrian; Stefanowicz, Magdalena; Matulewicz, Natalia; Nikołajuk, Agnieszka; Karczewska-Kupczewska, Monika. Inverse regulation of serum osteoprotegerin and B-type natriuretic peptide concentrations by free fatty acids elevation in young healthy humans. Nutrients 2022, 14(4): art. no 837 (1-10) (10.3390/nu14040837).
  2. Karczewska-Kupczewska, Monika; Nikołajuk, Agnieszka; Kondraciuk, Marcin; Stachurska, Zofia; Dubatówka, Marlena; Szpakowicz, Anna; Strączkowski, Marek; Kowalska, Irina; Kamiński, Karol. The relationships between FLAIS, a novel insulin sensitivity index, and cardiovascular risk factors in a population-based study. Cardiovascular Diabetology 2022, 21: art. no 55 (1-10) (10.1186/s12933-022-01491-y).
  3. Stefanowicz, Magdalena; Nikołajuk, Agnieszka; Matulewicz, Natalia; Strączkowski, Marek; Karczewska-Kupczewska, Monika. Skeletal muscle RUNX1 is related to insulin sensitivity through its effect on myogenic potential. European Journal of Endocrinology 2022, 187(1): 143-157 (10.1530/EJE-21-0776).
  4. Strączkowski, Marek; Nikołajuk, Agnieszka; Stefanowicz, Magdalena; Matulewicz, Natalia; Fernández-Real, José M.; Karczewska-Kupczewska, Monika. Adipose tissue and skeletal muscle expression of genes associated with thyroid hormone action in obesity and insulin resistance. Thyroid 2022, 32(2): 206-214 (10.1089/thy.2021.0351).
  5. Strączkowski, Marek; Stefanowicz, Magdalena; Matulewicz, Natalia; Nikołajuk, Agnieszka; Karczewska-Kupczewska, Monika. Relation of adipose tissue and skeletal muscle FKBP5 expression with insulin sensitivity and the regulation of FKBP5 by insulin and free fatty acids. Endocrine 2022, 76: 536-542 (10.1007/s12020-022-03018-7).

2021

  1. Karczewska-Kupczewska, Monika; Nikołajuk, Agnieszka; Stefanowicz, Magdalena; Matulewicz, Natalia; Arnoriaga-Rodriguez, Maria; Fernandez-Real, Jose M.; Strączkowski, Marek. Novel laboratory index, based on fasting blood parameters, accurately reflects insulin sensitivity. Journal of Clinical Endocrinology & Metabolism 2021, 106(12): e5208-e5221 (10.1210/clinem/dgab489).
  2. Rydzewska, Marta; Nikołajuk, Agnieszka; Matulewicz, Natalia; Stefanowicz Magdalena; Karczewska-Kupczewska, Monika. Serum secreted frizzled-related protein 5 in relation to insulin sensitivity and its regulation by insulin and free fatty acids. Endocrine 2021, 74(2): 300-307 (10.1007/s12020-021-02793-z).

2020

  1. Karczewska-Kupczewska, Monika; Nikołajuk, Agnieszka; Majewski, Radosław; Filarski, Remigiusz; Stefanowicz, Magdalena; Matulewicz, Natalia; Strączkowski, Marek. Changes in adipose tissue lipolysis gene expression and insulin sensitivity after weight loss. Endocrine Connections 2020, 9(2): 90-100 (doi: 10.1530/EC-19-0507).
  2. Karczewska-Kupczewska, Monika; Nikołajuk, Agnieszka; Stefanowicz, Magdalena; Matulewicz, Natalia; Kowalska, Irina; Strączkowski, Marek. Serum and adipose tissue chemerin is differentially related to insulin sensitivity. Endocrine Connections 2020, przyjęta do druku (doi: 10.1530/EC-20-0084).

2018

  1. Karczewska-Kupczewska, Monika; Nikołajuk, Agnieszka; Filarski, Remigiusz; Majewski, Radosław; Tarasów, Eugeniusz. Intralipid/heparin infusion alters the brain metabolites assessed with 1H-MRS spectroscopy in young healthy men. Journal of Clinical Endocrinology & Metabolism 2018, 103(7): 2563-2570 (doi: 10.1210/jc.2018-00107).
  2. Katsyuba, Elena; Mottis, Adrienne; Ziętak, Marika; De Franco, Francesca; van der Velpen, Vera; Gariani, Karim; Ryu, Dongryeol; Cialabrini, Lucia; Matilainen, Olli; Liscio, Paride; Giacchè, Nicola; Stokar-Regenscheit, Nadine; Legouis, David; de Seigneux, Sophie; Ivanisevic, Julijana; Raffaelli, Nadia; Schoonjans, Kristina; Pellicciari, Roberto; Auwerx, Johan. De novo NAD+ synthesis enhances mitochondrial function and improves health. Nature 2018, 563: 354-359 (doi: 10.1038/s41586-018-0645-6).
  3. Nikołajuk, Agnieszka; Matulewicz, Natalia; Stefanowicz, Magdalena; Karczewska-Kupczewska, Monika. Serum matrix metalloproteinase 9 and macrophage migration inhibitory factor (MIF) are increased in young healthy nonobese subjects with positive family history of type 2 diabetes. International Journal of Endocrinology 2018, 2018: art. no 3470412 (1-7) (doi: 10.1155/2018/3470412).
  4. Stefanowicz, Magdalena; Nikołajuk, Agnieszka; Matulewicz, Natalia; Karczewska-Kupczewska, Monika. Adipose tissue, but not skeletal muscle, sirtuin 1 expression is decreased in obesity and related to insulin sensitivity. Endocrine 2018, 60(2): 263-271 (doi: 10.1007/s12020-018-1544-1).
  5. Strączkowski, Marek; Nikołajuk, Agnieszka; Majewski, Radosław; Filarski, Remigiusz; Stefanowicz, Magdalena; Matulewicz, Natalia; Karczewska-Kupczewska, Monika. The effect of moderate weight loss, with or without (1,3)(1,6)-β-glucan addition, on subcutaneous adipose tissue inflammatory gene expression in young subjects with uncomplicated obesity. Endocrine 2018, 61(2): 275-284 (doi: 10.1007/s12020-018-1619-z).
  6. Velazquez-Villegas, Laura A.; Perino, Alessia; Lemos, Vera; Ziętak, Marika; Nomura, Mitsunori; Pols, Thijs W. H.; Schoonjans, Kristina. TGR5 signalling promotes mitochondrial fission and beige remodelling of white adipose tissue. Nature Communications 2018, 9(1): art. no 245 (1-13) (doi: 10.1038/s41467-017-02068-0).

2017

  1. Matulewicz, Natalia; Stefanowicz, Magdalena; Nikołajuk, Agnieszka; Karczewska-Kupczewska, Monika. Markers of adipogenesis, but not inflammation in adipose tissue, are independently related to insulin sensitivity. Journal of Clinical Endocrinology & Metabolism 2017, 102(8): 3040-3049 (doi: 10.1210/jc.2017-00597).

2016

  1. Adamska, Agnieszka; Karczewska-Kupczewska, Monika; Łebkowska, Agnieszka; Milewski, Robert; Górska, Maria; Otziomek, Elżbieta; Nikołajuk, Agnieszka; Wołczyński, Sławomir; Kowalska, Irina. Serum irisin and its regulation by hyperinsulinemia in women with polycystic ovary syndrome. Endocrine Journal 2016, 63(12): 1107-1112 (doi: 10.1507/endocrj.EJ16-0249).
  2. Karczewska-Kupczewska, Monika; Stefanowicz, Magdalena; Matulewicz, Natalia; Nikołajuk, Agnieszka; Strączkowski, Marek. Wnt signaling genes in adipose tissue and skeletal muscle of humans with different degrees of insulin sensitivity. Journal of Clinical Endocrinology & Metabolism 2016, 101(8): 3079-3087 (doi: 10.1210/jc.2016-1594).
  3. Łebkowska, Agnieszka; Adamska, Agnieszka; Karczewska-Kupczewska, Monika; Nikołajuk, Agnieszka; Otziomek, Elżbieta; Milewski, Robert; Górska, Maria; Wołczyński, Sławomir; Kowalska, Irina. Serum anti-Müllerian hormone concentration in women with polycystic ovary syndrome and type 1 diabetes mellitus. Metabolism: Clinical and Experimental 2016, 65(5): 804-811 (doi: 10.1016/j.metabol.2016.02.005).
  4. Matulewicz, Natalia; Karczewska-Kupczewska, Monika. Insulinooporność a przewlekła reakcja zapalna [Insulin resistance and chronic inflammation]. Postępy Higieny i Medycyny Doświadczalnej 2016, 70: 1245-1257 (pdf).
  5. Moreno-Navarrete, Jose M.; Blasco, Gerard; Xifra, Gemma; Karczewska-Kupczewska, Monika; Stefanowicz, Magdalena; Matulewicz, Natalia; Puig, Josep; Ortega, Francisco; Ricart, Wilfredo; Strączkowski, Marek; Fernández-Real, Jose M. Obesity is associated with gene expression and imaging markers of iron accumulation in skeletal muscle. Journal of Clinical Endocrinology & Metabolism 2016, 101(3): 1282-1289 (doi: 10.1210/jc.2015-3303).

2015

  1. Nikołajuk, Agnieszka; Karczewska-Kupczewska, Monika; Strączkowski, Marek. Relationship between serum IL-12 and p40 subunit concentrations and lipid parameters in overweight and obese women. Metabolic Syndrome and Related Disorders 2015, 13(8): 336-342 (doi: 10.1089/met.2014.0164).
  2. Stefanowicz, Magdalena; Strączkowski, Marek; Karczewska-Kupczewska, Monika. Rola SIRT1 w patogenezie insulinooporności mięśni szkieletowych [The role of SIRT1 in the pathogenesis of insulin resistance in skeletal muscle]. Postępy Higieny i Medycyny Doświadczalnej 2015, 69: 63-68 (doi: 10.5604/17322693.1136379).

2014

  1. Adamska, Agnieszka; Karczewska-Kupczewska, Monika; Nikołajuk, Agnieszka; Otziomek, Elżbieta; Górska, Maria; Kowalska, Irina; Strączkowski, Marek. Relationships of serum soluble E-selectin concentration with insulin sensitivity and metabolic flexibility in lean and obese women. Endocrine 2014, 45(3): 422-429 (doi: 10.1007/s12020-013-0025-9).
  2. Ortega, Francisco J.; Mercader, Josep M.; Moreno-Navarrete, Jose M.; Rovira, Oscar; Guerra, Ester; Esteve, Eduardo; Xifra, Gemma; Martínez, Cristina; Ricart, Wifredo; Rieusset, Jennifer; Rome, Sophie; Karczewska-Kupczewska, Monika; Strączkowski, Marek; Fernández-Real, Jose M. Profiling of circulating microRNAs reveals common microRNAs linked to type 2 diabetes that change with insulin sensitization. Diabetes Care 2014, 37(5): 1375-1383 (doi: 10.2337/dc13-1847).
  3. Sala, David; Ivanova, Saška; Plana, Natàlia; Ribas, Vicent; Duran, Jordi; Bach, Daniel; Turkseven, Saadet; Laville, Martine; Vidal, Hubert; Karczewska-Kupczewska, Monika; Kowalska, Irina; Strączkowski, Marek; Testar, Xavier; Palacín, Manuel; Sandri, Marco; Serrano, Antonio L.; Zorzano, Antonio. Autophagy-regulating TP53INP2 mediates muscle wasting and is repressed in diabetes. Journal of Clinical Investigation 2014, 124(5): 1914-1927 (doi: 10.1172/JCI72327).

2013

  1. Adamska, Agnieszka; Karczewska-Kupczewska, Monika; Nikołajuk, Agnieszka; Otziomek, Elżbieta; Górska, Maria; Kowalska, Irina; Strączkowski, Marek. Normal metabolic flexibility despite insulin resistance in women with polycystic ovary syndrome. Endocrine Journal 2013, 60(9): 1107-1113 (doi: 10.1507/endocrj.EJ13-0115).
  2. Karczewska-Kupczewska, Monika; Adamska, Agniewszka; Nikołajuk, Agnieszka; Otziomek, Elżbieta; Górska, Maria; Kowalska, Irina; Strączkowski, Marek. Circulating interleukin 6 and soluble forms of its receptors in relation to resting energy expenditure in women with anorexia nervosa. Clinical Endocrinology 2013, 79(6): 812-816 (doi: 10.1111/cen.12118).
  3. Karczewska-Kupczewska, Monika; Tarasów, Eugeniusz; Nikołajuk, Agnieszka; Stefanowicz, Magdalena; Matulewicz, Natalia; Otziomek, Elżbieta; Górska, Maria; Strączkowski, Marek; Kowalska, Irina. The effect of insulin infusion on the metabolites in cerebral tissues assessed with proton magnetic resonance spectroscopy in young healthy subjects with high and low insulin sensitivity. Diabetes Care 2013, 36(9): 2787-2793 (doi: 10.2337/dc12-1437).
  4. Kowalska, Irina; Karczewska-Kupczewska, Monika; Adamska, Agnieszka; Nikołajuk, Agnieszka; Otziomek, Elżbieta; Strączkowski, Marek. Serum visfatin is differentially regulated by insulin and free Fatty acids in healthy men. Journal of Clinical Endocrinology & Metabolism 2013, 98(2): E293-E297 (doi: 10.1210/jc.2012-2818).
  5. Strączkowski, Marek; Karczewska-Kupczewska, Monika; Adamska, Agnieszka; Otziomek, Elżbieta; Kowalska, Irina; Nikołajuk, Agnieszka. Serum fibroblast growth factor 21 in human obesity: regulation by insulin infusion and relationship with glucose and lipid oxidation. International Journal of Obesity 2013, 37(10): 1386-1390 (doi: 10.1038/ijo.2013.10).

2012

  1. Karczewska-Kupczewska, Monika; Kowalska, Irina; Nikołajuk, Agnieszka; Adamska, Agnieszka; Zielińska, Magdalena; Kamińska, Natalia; Otziomek, Elżbieta; Górska, Maria; Strączkowski, Marek. Circulating brain-derived neurotrophic factor concentration is downregulated by intralipid/heparin infusion or high-fat meal in young healthy male subjects. Diabetes Care 2012, 35(2): 358-362 (doi: 10.2337/dc11-1295).
  2. Karczewska-Kupczewska, Monika; Lelental, Natalia; Adamska, Agnieszka; Nikołajuk, Agnieszka; Kowalska, Irina; Górska, Maria; Zimmermann, Rudiger; Kornhuber, Johannes; Strączkowski, Marek; Lewczuk, Piotr. The influence of insulin infusion on the metabolism of amyloid β peptides in plasma. Alzheimer’s & Dementia 2012, 9(4): 400-405 (doi: 10.1016/j.jalz.2012.01.013).

Read more

Achievements PoMD

  1. Participation in the development of simple and accurate method of assessing insulin sensitivity, FLAIS (Fasting Laboratory Assessment of Insulin Sensitivity), which allows to identify insulin resistance even in the population without overt metabolic disturbances.
  2. Demonstration of altered adipose tissue and skeletal muscle expression of thyroid hormone-related genes in obesity, which indicates a decreased tissue thyroid hormone action.
  3. Demonstration that transcription faction RUNX1 in skeletal muscle is associated with insulin sensitivity mainly through its effect on myogenesis. These data indicate that myogenic/regenerative potential of adult skeletal muscle may be an important determinant of insulin action.
  4. Demonstration weight loss in subjects with uncomplicated obesity is not associated with a reduction in adipose tissue inflammation, but excessive lipolysis may prevent an improvement in insulin sensitivity during weight loss.

Read more

Current projects PoMD

  1. The search for the novel mechanisms linking intracellular calcium flux regulation with insulin sensitivity response to regular physical exercise – grant from National Science Centre (NCN nr 2021/41/B/NZ7/03948).

Read more

Equipment and applied methods B&PoHR

Research methods and equipment

Cell and molecular biology methods:

  • Isolation and culture of primary cells,
  • Work with cell lines:
    • culture of adherent and suspension cells,
    • transfection of cells,
    • lentiviral transduction of cells,
  • Isolation of DNA and RNA from tissues, cultured cells and body fluids,
  • Gene expression analysis by real-time RT PCR,
  • Analysis of gene polymorphisms by DNA sequencing,
  • Western-blot analysis of protein expression;,
  • FACS,
  • Detection of specific DNA fragments using Southern blot hybridization.

Equipment:

  • HERASAFE KS ThermoScientific laminar flow cell culture chamber,
  • cell culture incubators,
  • RealTime PCR Applied Biosystems Step One Plus,
  • Pegasus 4D, GCxGC TOF MS,
  • IN Cell Analyzer 2000HS,
  • Olympus CKX41 brightfield inverted microscope,
  • Tecan infinite m200pro plate reader,
  • DNA/RNA and protein electrophoresis apparatus with comb kit,
  • electro-transfer unit,
  • electrophoresis apparatus with comb set,
  • CASA system for computerised semen analysis,
  • autoclave,
  • ultrasonic cleaner Elma Elmasonic S 100H,
  • dry sterilisation oven,
  • UltraTurax homogeniser,
  • ThermoScientific STR8 centrifuge with cooling and variable rotors for 1.5, 2.0, 15 and 50 ml tubes,
  • laboratory centrifuge with cooling.

Read more

Publications B&PoHR

2025

  1. Rahman, Nafis A.; Chruściel, Marcin; Ponikwicka-Tyszko, Donata orcid; Pulawska-Moon, Kamila; Doroszko, Milena; Stelmaszewska, Joanna; Keuzer, Oliver J.; Rivero-Muller, Adolfo; Bernaczyk, Piotr; Zalewski, Grzegorz; Guo, Peilan; Toppari, Jorma; Li, Xiangdong; Zięcik, Adam J. orcid; Wołczyński, Sławomir orcid; Huhtaniemi, Ilpo. Targeted destruction of follicle stimulating hormone receptor-positive cancer cells in vitro and in vivo by a lytic peptide Phor21-FSHβ conjugate. Molecular Medicine 2025, 31(1): art. no 224 (1-17) (10.1186/s10020-025-01292-5).
  2. Rahman, Nafis A.; Chruściel, Marcin; Ponikwicka-Tyszko, Donata orcid; Puławska-Moon, Kamila; Stelmaszewska, Joanna; Doroszko, Milena; Kreuzer, Oliver J.; Rivero-Muller, Adolfo; Li, Xiangdong; Zięcik, Adam J. orcid; Wołczyński, Sławomir orcid; Huhtaniemi, Ilpo T.. Hecate-FSHβ33-53C/S lytic peptide conjugate selectively kills targeted follicle stimulating hormone receptor (FSHR)-positive cancer cells. Biomedicine & Pharmacotherapy 2025, 186: art. no 118022 (1-10) (10.1016/j.biopha.2025.118022).
  3. Schiele, Phillip; Sada Japp, Alberto; Stark, Regina; Sattelberg, Joanna J.; Nikolaou, Christos; Kornhuber, Gereon; Abbasi, Parya; Ding, Nina; Rosnev, Stanislav; Meinke, Stefan; Mühle, Kerstin; Loyal, Lucie; Braun, Julian; Dingeldey, Manuela; Durlanik, Sibel; Matzmohr, Nadine; Ponikwicka-Tyszko, Donata orcid; Wołczyński, Sławomir orcid; Rahman,Nafis A.; Taniuchi, Ichiro; Schlickeiser, Stephan; Giesecke-Thiel, Claudia; Blankenstein, Thomas; Na, Il-Kang; Thiel, Andreas; Frentsch, Marco. CD8+ T cell-derived CD40L mediates non-canonical cytotoxicity in CD40-expressing cancer cells. Science Advances 2025, 11(21): art. no eadr9331 (1-14) (10.1126/sciadv.adr9331).
  4. Zhang, Shanshan; Liu, Yajing; Wang, Mingming; Ponikwicka-Tyszko, Donata orcid; Wołczyński, Sławomir orcid; Chen, Li; Huang, Xuan; Yao, Bing; Rahman, Nafis A; Li, Xiangdong. miR-423-3p inhibits CTNNBIP1/WNT preventing hyperandrogenic PCOS. Biology of Reproduction 2025, 113(4): 856-869 (10.1093/biolre/ioaf116).

2024

  1. Krentowska, Anna; Ponikwicka-Tyszko, Donata orcid; Łebkowska, Agnieszka; Adamska, Agnieszka; Sztachelska, Maria orcid; Milewska, Gabriela; Hryniewicka, Justyna; Wołczyński, Sławomir orcid; Kowalska, Irina. Serum expression levels of selected microRNAs and their association with glucose metabolism in young women with polycystic ovary syndrome. Polish Archives of Internal Medicine – Polskie Archiwum Medycyny Wewnętrznej 2024, 134(1): art. no 16637 (1-5) (10.20452/pamw.16637).

  2. Milewska,Gabriela; Ponikwicka-Tyszko, Donata orcid; Bernaczyk, Piotr; Lupu, Oana; Szamatowicz, Michał; Sztachelska, Maria orcid; Pilaszewicz-Puza, Agata; Koda, Mariusz; Bielawski, Tomasz orcid; Zbucka-Kretowska, Monika; Pawelczyk, Adam; Tomaszewski, Jakub; Li, Xiangdong; Huhtaniemi, Ilpo T.; Wołczyński, Sławomir orcid; Rahman, Nafis A. Functional evidence for two distinct mechanisms of action of progesterone and selective progesterone receptor modulator on uterine leiomyomas. Fertility and Sterility 2024, 122(2): 341-351 (10.1016/j.fertnstert.2024.02.046).

  3. Palak, Ewelina orcid; Ponikwicka-Tyszko, Donata orcid; Puławska-Moon, Kamila; Sztachelska, Maria orcid; Milewska, Gabriela; Modzelewska, Beata; Kleszczewski, Tomasz; Koivukoski, Maria L.; Bernaczyk, Piotr; Razak Hady, Hady; Gołaszewski, Piotr; Łupińska, Aleksandra N. orcid; Kulikowski, Marek; Lemancewicz, Adam; Huhtaniemi, Ilpo T.; Wołczyński, Sławomir orcid; Rahman, Nafis A. Revisiting the follicle-stimulation hormone receptor expression and function in human myometrium and adipose tissue. Molecular Medicine 2024, 30: art. no 241 (1-14) (10.1186/s10020-024-01015-2).

  4. Puławska-Moon, Kamila; Ponikwicka-Tyszko, Donata orcid; Lebiedzińska, Weronika; Pilaszewicz-Puza, Agata; Bernaczyk, Piotr; Koda, Mariusz; Lupu, Oana; Milewska, Gabriela; Huang, Chen-Che Jeff; Zheng, Huifei; Schiele, Phillip; Na, Il-Kang; Frentsch, Marco; Li, Xiangdong; Toppari, Jorma; Wołczyński, Sławomir orcid; Coelingh Bennink, Herjan J. T.; Huhtaniemi, Ilpo T.; Rahman, Nafis A. Novel ectopic expression of zona pellucida 3 glycoprotein in lung cancer promotes tumor growth. International Journal of Cancer 2024, 155(10): 1846-1857 (10.1002/ijc.35098).

  5. Szucio, Weronika; Bernaczyk, Piotr; Ponikwicka-Tyszko, Donata orcid; Milewska, Gabriela; Pawelczyk, Adam; Wołczyński, Sławomir orcid; Rahman, Nafis A. Progesterone signaling in uterine leiomyoma biology: Implications for potential targeted therapy. Advances in Medical Sciences 2024, 69(1): 21-28 (10.1016/j.advms.2024.01.001).

2023

  1. Kamińska, Joanna; Koper-Lenkiewicz, Olga M.; Ponikwicka-Tyszko, Donata; Lebiedzińska, Weronika; Palak, Ewelina; Sztachelska, Maria; Bernaczyk, Piotr; Dorf, Justyna; Guzińska-Ustymowicz, Katarzyna; Zaręba, Konrad; Wołczyński, Sławomir; Rahman, Nafis A.; Dymicka-Piekarska, Violetta. New Insights on the Progesterone (P4) and PGRMC1/NENF Complex Interactions in Colorectal Cancer Progression. Cancers 2023, 15(20): art. no 5074 (1-21) (10.3390/cancers15205074).
  2. Liu, Yajing; Zhang, Shanshan; Chen, Li; Huang, Xuan; Wang, Mingming; Ponikwicka-Tyszko, Donata; Rahman, Nafis A.; Wołczyński, Sławomir; Yao, Bing; Li, Xiangdong. The molecular mechanism of miR-96-5p in the pathogenesis and treatment of polycystic ovary syndrome. Translational Research 2023, 256: 1-13 (10.1016/j.trsl.2022.12.007).
  3. Palak, Ewelina; Lebiedzińska, Weronika; Lupu, Oana; Puławska, Kamila; Anisimowicz, Sławomir; Mieczkowska, Aleksandra N.; Sztachelska, Maria; Niklińska, Gabriella N.; Milewska, Gabriela; Łukasiewicz, Monika; Ponikwicka-Tyszko, Donata; Huhtaniemi, Ilpo; Wołczyński, Sławomir. Molecular insights underlying the adverse effects of bisphenol A on gonadal somatic cells’ steroidogenic activity. Reproductive Biology 2023, 23(2): art. no 100766 (1-12) (10.1016/j.repbio.2023.100766).
  4. Zhang, Shanshan; Liu, Yajing; Wang, Mingming; Ponikwicka-Tyszko, Donata; Ma, Wenqiang; Krentowska, Anna; Kowalska, Irina; Huhtaniemi, Ilpo; Wołczyński, Slawomir; Rahman, Nafis A.; Li, Xiangdong. Role and mechanism of miR-335-5p in the pathogenesis and treatment of polycystic ovary syndrome. Translational Research 2023, 252: 64-78 (10.1016/j.trsl.2022.07.007).

2022

  1. Nowak, Karolina; Jabłońska, Ewa; Garley, Marzena; Iwaniuk, Agnieszka; Radziwon, Piotr; Wołczyński, Sławomir; Ratajczak-Wrona, Wioletta. Investigation of estrogen-like effects of parabens on human neutrophils. Environmental Research 2022, 214(Part 1): art. no 113893 (1-12) (10.1016/j.envres.2022.113893).
  2. Omeljaniuk, Wioleta J.; Charkiewicz, Angelika E.; Garley, Marzena; Ratajczak-Wrona, Wioletta; Czerniecki, Jan; Jabłońska, Ewa; Cechowska-Pasko, Marzanna; Miltyk, Wojciech. Bisphenol A: potential factor of miscarriage in women in the context of the phenomenon of neutrophil extracellular traps. Archivum Immunologiae et Therapiae Experimentalis 2022, 70: art. no 24 (1-10) (10.1007/s00005-022-00661-w).
  3. Puławska, Kamila; Ponikwicka-Tyszko, Donata; Lebiedzińska, Weronika; Guod, Peilan; Bernaczyk, Piotr; Pilaszewicz-Puza, Agata; Li, Xiangdong; Chruściel, Marcin; Lupu, Oana; Leskinen, Sini; Makela, Juho-Antti; Toppari, Jorma; Wołczyński, Slawomir; Coelingh Bennink, Herjan J.T.; Huhtaniemi, Ilpo; Rahman, Nafis A. Novel expression of zona pellucida 3 protein in normal testis; potential functional implications. Molecular and Cellular Endocrinology 2022, 539: art. no 111502 (1-10) (10.1016/j.mce.2021.111502).
  4. Sztachelska, Maria; Ponikwicka-Tyszko, Donata; Martínez-Rodrigo, Lydia; Bernaczyk, Piotr; Palak, Ewelina; Półchłopek, Weronika; Bielawski, Tomasz; Wołczyński, Sławomir. Functional implications of estrogen and progesterone receptors expression in adenomyosis, potential targets for endocrinological therapy. Journal of Clinical Medicine 2022, 11(15): art. no 4407 (1-16) (10.3390/jcm11154407).

2021

  1. Komarowska, Marta D.; Grubczak, Kamil; Czerniecki, Jan; Hermanowicz, Adam; Hermanowicz, Justyna M.; Dębek, Wojciech; Matuszczak, Ewa. Identification of the bisphenol A (BPA) and the two analogues BPS and BPF in cryptorchidism. Frontiers in Endocrinology 2021, 12: art. no 694669 (1-9) (10.3389/fendo.2021.694669).
  2. Łukasiewicz, Monika; Czerniecki, Jan; Ponikwicka-Tyszko, Donata; Sztachelska, Maria; Hryniewicka, Marta; Nalewajko-Sieliwonik, Edyta; Wiczkowski, Wiesław; Banaszewska, Beata; Milewski, Robert; Toppari, Jorma; Huhtaniemi, Ilpo; Rahman, Nafis A.; Wołczyński, Sławomir. Placenta is capable of protecting the male fetus from exposure to environmental bisphenol A. Exposure and Health 2021, 12: 1-14 (10.1007/s12403-020-00358-5).
  3. Palak, Ewelina; Lebiedzińska, Weronika; Anisimowicz, Sławomir; Sztachelska, Maria; Pierzyński, Piotr; Wiczkowski, Wiesław; Żelazowska-Rutkowska, Beata; Niklińska, Gabriella N.; Ponikwicka-Tyszko, Donata; Wołczyński, Sławomir. The association between bisphenol A, steroid hormones, and selected microRNAs levels in seminal plasma of men with Infertility. Journal of Clinical Medicine 2021, 10(24): art. no 5945 (1-11) (10.3390/jcm10245945).
  4. Ratajczak-Wrona, Wioletta; Garley, Marzena; Rusak, Małgorzata; Nowak, Karolina; Czerniecki, Jan; Wołosewicz, Katarzyna; Dąbrowska, Milena; Wołczyński, Sławomir; Radziwoń, Piotr; Jablońska, Ewa. Sex-dependent dysregulation of human neutrophils responses​ by bisphenol A. Environmental Health 2021, 20(1): art. no 5 (1-18) (10.21203/rs.3.rs-26406/v1).

2020

  1. Ponikwicka-Tyszko, Donata; Chruściel, Marcin; Puławska, Kamila; Bernaczyk, Piotr; Sztachelska, Maria; Guo, Peilan; Li, Xiangdong; Toppari, Jorma; Huhtaniemi, Ilpo T.; Wołczyński, Sławomir; Rahman, Nafis A. Mifepristone treatment promotes testicular leydig cell tumor progression in transgenic mice. Cancers 2020, 12(11): art. no 3263 (1-18) (10.3390/cancers12113263).

2019

  1. Chruściel, Marcin; Ponikwicka-Tyszko, Donata; Wołczyński, Sławomir; Huhtaniemi, Ilpo; Rahman, Nafis A. Extragonadal FSHR expression and function – Is it real?. Frontiers in Endocrinology 2019, 10: art. no 32 (1-13) (doi: 10.3389/fendo.2019.00032).
  2. Kowalczyk-Zięba, Ilona; Wocławek-Potocka, Izabela; Waśniewski, Tomasz; Boruszewska, Dorota; Grycmacher, Katarzyna; Sinderewicz, Emilia; Staszkiewicz, Joanna; Wołczyński, Sławomir. LPAR2 and LPAR4 are the main receptors responsible for LPA actions in ovarian endometriotic cysts. Reproductive Sciences 2019, 26(1): 139-150 (doi: 10.1177/1933719118766263).
  3. Liu, Mei; Du, Yaqi; Li, Haiwen; Wang, Li; Ponikwicka-Tyszko, Donata; Lebiedzińska, Weronika; Pilaszewicz-Puza, Agata; Liu, Huijiao; Zhou, Lijun; Fan, Hanlu; Wang, Mingming; You, Hua; Wolczyński, Sławomir; Rahman, Nafis; Guo, Yang-Dong; Li, Xiangdong. Cyanidin-3-o-glucoside pharmacologically inhibits tumorigenesis via estrogen receptor β in melanoma mice. Frontiers in Oncology 2019, 9: art. no 1110 (1-18) (doi: 10.3389/fonc.2019.01110).
  4. Ponikwicka-Tyszko, Donata; Chruściel, Marcin; Stelmaszewska, Joanna; Bernaczyk, Piotr; Chruściel, Paulina; Sztachelska, Maria; Scheinin, Mika; Bidziński, Mariusz; Szamatowicz, Jacek; Huhtaniemi, Ilpo T.; Wolczynski, Slawomir; Rahman, Nafis A. Molecular mechanisms underlying mifepristone’s agonistic action on ovarian cancer progression. EBioMedicine 2019, 47: 170-183 (doi: 10.1016/j.ebiom.2019.08.035).
  5. Puławska, Kamila; Doroszko, Milena; Chruściel, Marcin; Ponikwicka-Tyszko, Donata; Wołczyński, Slawomir; Toppari, Jorma; Huhtaniemi, Ilpo; Rahman, Nafis A. Mouse models of adrenal tumors responsive to gonadotropin-releasing hormone and gonadotropins. Current Opinion in Endocrine and Metabolic Research 2019, 8: 189-194 (doi: 10.1016/j.coemr.2019.08.014).
  6. Ratajczak-Wrona, Wioletta; Nowak, Karolina; Garley, Marzena; Grubczak, Kamil; Dąbrowska, Dorota; Iwaniuka, Agnieszka; Wilk, Sara; Moniuszko, Marcin; Czerniecki, Jan; Wołczyński, Sławomir; Jablońska, Ewa. Expression of serine proteases in neutrophils from women and men: regulation by endocrine disruptor bisphenol A. Environmental Toxicology and Pharmacology 2019, 71: art. no 103212 (1-10) (doi: 10.1016/j.etap.2019.103212).
  7. Sztachelska, Maria; Ponikwicka-Tyszko, Donata; Sokołowska, Gabriela; Anisimowicz, Sławomir; Czerniecki, Jan; Lebiedzińska, Weronika; Zbucka-Kretowska, Monika; Zygmunt, Marek; Wołczyński, Sławomir; Pierzyński, Piotr. Oxytocin antagonism reverses the effects of high estrogen levels and oxytocin on decidualization and cyclooxygenase activity in endometrial tissues. Reproductive BioMedicine Online 2019, 39(5): 737-744 (doi: 10.1016/j.rbmo.2019.06.002).
  8. Zbucka-Krętowska, Monika; Łazarek, Urszula; Miltyk, Wojciech; Sidorkiewicz, Iwona; Pierzyński, Piotr; Milewski, Robert; Wołczyński, Sławomir; Czerniecki, Jan. Simultaneous analysis of bisphenol A fractions in maternal and fetal compartments in early second trimester of pregnancy. Journal of Perinatal Medicine 2019, 47(7): 765-770 (doi: 10.1515/jpm-2019-0040).

2018

  1. Huhtaniemi, Ilpo; Hovatta, Outi; La Marca, Antonio; Livera, Gabriel; Monniaux, Danielle; Persani, Luca; Heddar, Abdelkader; Jarząbek, Katarzyna; Laisk-Podar, Triin; Salumets, Andres; Tapanainen, Juha S.; Veitia, Reiner A.; Visser, Jenny A.; Wieacker, Peter; Wołczyński, Sławomir; Misrahi, Micheline. Advances in the molecular pathophysiology, genetics, and treatment of primary ovarian insufficiency. Trends in Endocrinology and Metabolism 2018, 29(6): 400-419 (doi: 10.1016/j.tem.2018.03.010).
  2. Sidorkiewicz, Iwona; Czerniecki, Jan; Jarząbek, Katarzyna; Zbucka-Krętowska, Monika; Wołczyński, Sławomir. Cellular, transcriptomic and methylome effects of individual and combined exposure to BPA, BPF, BPS on mouse spermatocyte GC-2 cell line. Toxicology and Applied Pharmacology 2018, 359: 1-11 (doi: 10.1016/j.taap.2018.09.006).
  3. Siemieniuk, Magdalena; Sosnowska, Katarzyna; Czerniecki, Jan; Czyżewska, Urszula; Winnicka, Katarzyna; Tylicki, Adam. Oxythiamine improves antifungal activity of ketoconazole evaluated in canine Malassezia pachydermatis strains. Veterinary Dermatology 2018, 29(6): 476-e160 (doi: 10.1111/vde.12688).
  4. Zbucka-Kretowska, Monika; Charkiewicz, Karol; Czerniecki, Jan; Gościk, Joanna; Wołczyński, Sławomir; Laudański, Piotr. Amniotic fluid angiogenic and inflammatory factor profiling in foetal down syndrome. Fetal Diagnosis and Therapy 2018, 44: 44-50 (doi: 10.1159/000478260).

2017

  1. Jarząbek, Katarzyna; Mikucka-Niczyporuk, Agnieszka; Bielawski, Tomasz; Milewski, Robert; Kubiak, Jacek Z.; Wołczyński, Sławomir. Evaluation of steroid receptors mRNA fingerprints in two groups of normozoospermic patients: men from unexplained infertility couples vs. men from couples with tubal factor infertility. Open Journal of Obstetrics and Gynecology 2017, 7(3): 290-302 (doi: 10.4236/ojog.2017.73031).
  2. Sidorkiewicz, Iwona; Zaręba, Kamil; Wołczyński, Sławomir; Czerniecki, Jan. Endocrine-disrupting chemicals – Mechanisms of action on male reproductive system. Toxicology and Industrial Health 2017, 33(7): 601-609 (doi: 10.1177/0748233717695160).
  3. Sokołowska, Gabriela; Ponikwicka-Tyszko, Donata; Sztachelska, Maria; Wołczyński, Sławomir. Wpływ progesteronu i octanu uliprystalu na wzrost i rozwój mięśniaków macicy. W: Badania i Rozwój MłodychNaukowców w Polsce. Choroby nowotworowe. Ed. Nyćkowiak, Jędrzej; Leśny Jacek. Wydawnictwo Młodzi Naukowcy, Poznań 2017 (ISBN 978-83-65917-01-0), 99-104.

2016

  1. Milewski, Robert; Czerniecki, Jan; Kuczyńska, Agnieszka; Stankiewicz, Bożena; Kuczyński, Waldemar. Morphokinetic parameters as a source of information concerning embryo developmental and implantation potential. Ginekologia Polska 2016, 87(10): 677-684 (doi: 10.5603/GP.2016.0067).
  2. Ponikwicka-Tyszko, Donata; Chruściel, Marcin; Stelmaszewska, Joanna; Bernaczyk, Piotr; Sztachelska, Maria; Sidorkiewicz, Iwona; Doroszko, Milena; Tomaszewski, Jakub; Tapanainen, Juha S.; Huhtaniemi, Ilpo; Wołczyński, Sławomir; Rahman, Nafis A. Functional expression of FSH receptor in endometriotic lesions. Journal of Clinical Endocrinology & Metabolism 2016, 101(7): 2905-2914 (doi: 10.1210/jc.2016-1014).
  3. Stelmaszewska, Joanna; Chruściel, Marcin; Doroszko, Milena; Akerfelt, Malin; Ponikwicka-Tyszko, Donata; Nees, Matthias; Frentsch, Marco; Li, Xiangdong; Kero, Jukka; Huhtaniemi, Ilpo; Wołczyński, Sławomir; Rahman, Nafis A. Revisiting the expression and function of follicle-stimulation hormone receptor in human umbilical vein endothelial cells. Scientific Reports 2016, 6: art. no 37095 (1-12) (doi: 10.1038/srep37095).

2015

  1. Choi, Jin-Ho; Balasubramanian, Ravikumar; Lee, Phil H.; Shaw, Natalie D.; Hall, Janet E.; Plummer, Lacey; Buck, Cassandra L.; Kottler, Marie-Laure; Jarząbek, Katarzyna; Wołczyński, Sławomir; Quinton, Richard; Latronico, Ana C.; Dode, Catherine; Ogata, Tsutomu; Kim, Hyung-Goo; Layman, Lawrence C.; Gusella, James F.; Crowley, William F. J. Expanding the spectrum of founder mutations causing isolated gonadotropin-releasing hormone deficiency. Journal of Clinical Endocrinology & Metabolism 2015, 100(10): E1378-E1385 (doi: 10.1210/jc.2015-2262).
  2. Malinowski, Paweł; Milewski, Robert; Ziniewicz, Piotr; Milewska, Anna J.; Czerniecki, Jan; Więsak, Teresa; Morgan, Allen; Surowik, Dariusz; Wołczyński, Sławomir. Classification of patients treated for infertility using the IVF method. Studies in Logic, Grammar and Rhetoric 2015, 43(56): 49-59 (doi: 10.1515/slgr-2015-0041).
  3. Mannelli, Chiara; Szóstek, Anna Z.; Łukasik, Karolina; Carotenuto, Claudiopietro; Ietta, Francesca; Romagnoli, Roberta; Ferretti, Cristina; Paulesu, Luana; Wołczyński, Sławomir; Skarżyński, Dariusz J. Bisphenol A modulates receptivity and secretory function of human decidual cells: an in vitro study. Reproduction 2015, 150(2): 115-125 (doi: 10.1530/REP-14-0601).
  4. Sztachelska, Maria; Czerniecki, Jan. Jakość nasienia. Czy to kwestia tylko męskiego zdrowia?. ARTNewsletter 2015, 9(2): 25-26 (pdf).

2014

  1. Brünnert, Daniela; Sztachelska, Maria; Bornkessel, Frauke; Treder, Nora; Wołczyński, Sławomir; Goyal, Pankaj; Zygmunt, Marek. Lysophosphatidic acid and sphingosine 1-phosphate metabolic pathways and their receptors are differentially regulated during decidualization of human endometrial stromal cells. Molecular Human Reproduction 2014, 20(10): 1016-1025 (doi: 10.1093/molehr/gau051).
  2. Malinowski, Paweł; Milewski, Robert; Ziniewicz, Piotr; Milewska, Anna J.; Czerniecki, Jan; Wołczyński, Sławomir. The use of data mining methods to predict the result of infertility treatment using the IVF ET method. Studies in Logic, Grammar and Rhetoric 2014, 39(52): 67-74 (doi: 10.2478/slgr-2014-0044).
  3. Rod, Anne; Jarząbek, Katarzyna; Wołczyński, Sławomir; Benhaim, Annie; Reznik, Yves; Denoual-Ziad, Christine; Herlicoviez, Michel; Mittre, Hervé. ESR1 and FSHR gene polymorphisms influence ovarian response to FSH in poor responder women with normal FSH levels. Endocrinology & Metabolic Syndrome 2014, 3(3): art. no 1000141 (1-5) (doi: 10.4172/2161-1017.1000141).
  4. Świątecka, Jolanta; Bielawski, Tomasz; Anchim, Tomasz; Leśniewska, Monika; Milewski, Robert; Wołczyński, Sławomir. Oocyte zona pellucida and meiotic spindle birefringence as a biomarker of pregnancy rate outcome in IVF-ICSI treatment [Dwójłomność osłonki przejrzystej i wrzeciona kariokinetycznego oocytu jako czynnik predykcji wskaźnika ciąż w leczeniu IVF-ET]. Ginekologia Polska 2014, 85(4): 264-271 (doi: 10.17772/gp/1722).

2013

  1. Delvaux, David; Kerff, Frederic; Murty, Mamidanna R. V. S.; Lakaye, Bernard; Czerniecki, Jan; Kohn, Gregory; Wins, Pierre; Herman, Raphael; Gabelica, Valerie; Heuze, Fabien; Tordoir, Xavier; Maree, Raphael; Matagne, Andre; Charlier, Paulette; De Pauw, Edwin; Bettendorff, Lucien. Structural determinants of specificity and catalytic mechanism in mammalian 25-kDa thiamine triphosphatase. Biochimica et Biophysica Acta-General Subjects 2013, 1830(10): 4513-4523 (doi: 10.1016/j.bbagen.2013.05.014).
  2. Jarząbek, Katarzyna; Koda, Mariusz; Walentowicz-Sadlecka, Małgorzata; Grabiec, Marek; Laudański, Piotr; Wołczyński, Sławomir. Altered expression of ERs, aromatase, and COX2 connected to estrogen action in type 1 endometrial cancer biology. Tumor Biology 2013, 34(6): 4007-4016 (doi: 10.1007/s13277-013-0991-9).
  3. Malinowski, Paweł; Milewski, Robert; Ziniewicz, Piotr; Milewska, Anna J.; Czerniecki, Jan; Wołczyński, Sławomir. Classification issue in the IVF ICSI/ET data analysis: early treatment outcomes prognosis. Studies in Logic, Grammar and Rhetoric 2013, 35(48): 103-115 (doi: 10.2478/slgr-2013-0034).
  4. Milewski, Robert; Milewska, Anna J.; Czerniecki, Jan; Leśniewska, Monika; Wołczyński, Sławomir. Analiza profilu demograficznego pacjentów leczonych z powodu niepłodności metodami rozrodu wspomaganego w latach 2005-2010 [Analysis of the demographic profile of patients treated for infertility using assisted reproductive techniques in 2005-2010]. Ginekologia Polska 2013, 84(7): 609-614 (doi: 10.17772/gp/1612).
  5. Patricelli, Dario; Sielezniew, Marcin; Ponikwicka-Tyszko, Donata; Ratkiewicz, Mirosław; Bonelli, Simona; Barbero, Francesca; Witek, Magdalena; Buś, Magdalena M.; Rutkowski, Robert; Balletto, Emilio. Contrasting genetic structure of rear edge and continuous range populations of a parasitic butterfly infected by Wolbachia. BMC Evolutionary Biology 2013, 13: art. no 14 (1-13) (doi: 10.1186/1471-2148-13-14).

2012

  1. Jarząbek, Katarzyna; Kozłowski, Leszek; Milewski, Robert; Wołczyński, Sławomir. KiSS1/GPR54 and estrogen-related gene expression profiles in primary breast cancer. Oncology Letters 2012, 3(4): 930-934 (doi: 10.3892/ol.2012.582).
  2. Jarząbek, Katarzyna; Wołczyński, Sławomir; Leśniewicz, Ryszard; Plessis, G.; Kottler, Marie-Laure. Evidence that FGFR1 loss-of-function mutations may cause variable skeletal malformations in patients with Kallmann syndrome. Advances in Medical Sciences 2012, 57(2): 314-321 (doi: 10.2478/v10039-012-0036-4).
  3. Milewski, Robert; Malinowski, Paweł; Milewska, Anna J.; Ziniewicz, Piotr; Czerniecki, Jan; Pierzyński, Piotr; Wołczyński, Sławomir. Classification issue in the IVF ICSI/ET data analysis. Studies in Logic, Grammar and Rhetoric 2012, 29(42): 75-86.
  4. Ponikwicka-Tyszko, Donata; Kotula-Balak, Małgorzata; Jarząbek, Katarzyna; Bilińska, Barbara; Wołczyński, Sławomir. The DAX1 mutation in a patient with hypogonadotropic hypogonadism and adrenal hypoplasia congenita causes functional disruption of induction of spermatogenesis. Journal of Assisted Reproduction and Genetics 2012, 29(8): 811-816 (doi: 10.1007/s10815-012-9778-y).
  5. Sielezniew, Marcin; Rutkowski, Robert; Ponikwicka-Tyszko, Donata; Ratkiewicz, Mirosław; Dziekańska, Izabela; Švitra, Giedrius. Differences in genetic variability between two ecotypes of the endangered myrmecophilous butterfly Phengaris (=Maculinea) alcon – the setting of conservation priorities. Insect Conservation and Diversity 2012, 5(3): 223-236 (doi: 10.1111/j.1752-4598.2011.00163.x).

Read more

Foreign co-operation B&PoHR

Collaborations

  • Prof. Nafis Rahman Department of Physiology, Institute of Biomedicine, Faculty of Medicine, University of Turku, Finland
  • Xiangdong Li State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, China
  • Prof. Marek Zygmunt Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe, Universitätsmedizin Greifswald, Germany
  • Prof. dr hab. Violetta Dymicka-Piekarska, Department of Clinical Laboratory Diagnostics, Faculty of Pharmacy with the Division of Laboratory Medicine Medical University of Białystok, Poland
  • Dr hab. Wioletta Ratajczak-Wrona, Departament of Immunology, Faculty of Pharmacy with the Division of Laboratory Medicine Medical University of Białystok, Poland

Read more

Current projects B&PoHR

Research projects:

  1. Establishment and characterisation of immortalised PCOS and control adipocyte cell lines – Statutory work for the year 2024.
  2. Studies on the mechanism of human cytomegalovirus persistence in reproductive tract cancer cells – Statutory work for the year 2023.
  3. Development of a research model of uterine dysfunction during the ovarian cycle and early pregnancy – Functional role of steroid hormone receptors in the development of receptive endometrium – Statutory work for the year 2022.
  4. Functional characterisation of ovarian-specific genes potentially involved in the pathophysiology of endometriosis (Polish Gynaecological Society Grant).
  5. The role of lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) and their receptors in the proliferation, migration and decidualization of human endometrial stromal cells (NCN Preludium, project nr: 2014/13/N/NZ4/04408).
  6. Molecular mechanisms of interaction between progesterone, mifepristone and nuclear and membrane progesterone receptors in gonadal cancer cells in vitro (NCN Preludium, project nr: 2013/09/N/NZ5/01831).
  7. The impact of antropogenic xenoestrogens in male infertility development (NCN Opus, project nr: 2012/05/B/NZ7/02391).

Read more