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Foreign co-operation BFoF

  1. Centre for Biomedicine and Community Health, Vietnam National University, Hanoi, Vietnam;
  2. Department of Animal Nutrition, Lithuanian University of Health Sciences, Kaunas, Lithuania;
  3. Department of Health Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy;
  4. Department of Animal Science, University of Manitoba, Winnipeg, Canada;
  5. Molecular Immunonutrition Group, Madrid Institute for Advanced Studies in Food (IMDEA-Food), Madrid, Spain.

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Achievements BFoF

  1. We have discovered that a regular eating of seeds from certain plants (hemp, flax, milk thistle) rich in polyunsaturated fatty acids and other important components, as well as defatted forms of these seeds, can be beneficial for health to the extent dependent on their amount, type of the diet used and genetic predispositions of the consumer (Opyd et al., Nutrients 2018; Jurgoński et al., J. Funct. Foods 2020). The inclusion of hemp seeds or milk thistle seeds into the diet is, among others, more effective in attenuating metabolic disorders specific to genetic obesity than the inclusion of oils from these seeds themselves, which indicates that polyunsaturated fatty acids are less responsible for their health effects than the other components, such as phenolic compounds or fibre (Opyd et al., J. Nutr. 2020; Opyd and Jurgoński, Sci. Rep. 2021).
  2. Research on enhancing the health-promoting properties of raspberries has shown that: 1) a higher grinding level of raspberry pomace increases the bioavailability of compounds enclosed in the seeds and the fiber matrix, and thus has a positive effect on the parameters of gastrointestinal tract, lipid metabolism, antioxidant status and the synthesis of bile acids in the liver of rats with disorders induced by a high-fat diet, 2) stimulating the gastrointestinal microbiota by enriching the diet with fructo-oligosaccharides increases the metabolism of raspberry polyphenols and intensifies the beneficial effects related to the regulation of lipid metabolism, antioxidant status and pro-inflammatory mechanisms in rats with disorders associated with nonalcoholic fatty liver (Fotschki et al., Food Res. Int. 2019 and 2022; Fotschki et al., J. Nutr. Biochem. 2017; Fotschki et al., Nutrients 2022).
  3. We have obtained empirical evidence to state that blackcurrant and strawberry pomace are a source of many valuable components, such as dietary fibre, polyphenols and lipids, mainly polyunsaturated fatty acids, the regular consumption of which may be beneficial for health to a degree depending on the type of diet used and the time of its supplementation (Jurgoński et al., Eur. J. Nutr., 2014, 2015 and 2016;  Jurgoński et al., Food Nutr. Res. 2015; Jurgoński et al., J. Funct. Foods 2016). The obtained results indicate the possibility of using preparations from blackcurrant and strawberry pomace, such as oils, polyphenolic extracts or fibre-phenolic preparations, in the prevention and treatment of diet-related diseases.
  4. We have discovered in in vivo experiments that mono- and dimeric ellagitannins are differently metabolised by intestinal microbiota and that is clearly reflected in organism biological response. Additionally, we observed that upon unfriendly large gut environment microbial enzymes are at larger amount released from the bacterial cells in order to obtain an additional energy and to optimize the digestion processes in that section of the gastrointestinal tract (Fotschki, Juśkiewicz et al.,  Nutrients 2018).
  5. We have reported that in comparison to a standard dietary copper source in rat feed (copper carbonate) copper nanoparticles possess stronger antibacterial properties in the large intestine, but they are excessively accumulated in brain tissue and may cause hepatic lesions. The latter detrimental action of nanoparticles can be ascribed to their enhanced absorption from the intestinal tract into blood stream (Cholewińska, <…>, Juśkiewicz, PLoS ONE 2018).
  6. We have observed that epigenetic changes and oxidation of lipids, proteins, and DNA in the heart and brain of rats resulting from the use of a high-fat diet cannot be limited by supplementing the diet with chromium. It was established that the use of chromium to supplement a high-fat diet intensifies the negative epigenetic and oxidative changes in the heart and brain, especially in the case of chromium nanoparticles (Dworzański, <…>, Juśkiewicz et al., Animals 2020).

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Current projects BFoF

  1. Nutritional and Metabolic Factors Affecting the Development of Disorders in Diet-Related Diseases (Internal Funds).
  2. How Phosphorus-Containing Food Additives Affect the Gut and Metabolic Health of the Body: Having the Guts to Tackle Phosphates (National Science Centre, Poland; project No. 2023/49/B/NZ9/01345; principal investigator: Assoc. Prof. A. Jurgoński).
  3. Development and Implementation of Innovative Functional Foods Targeting the Prevention of Diet-Related Diseases (National Centre for Research and Development, project No. NUTRITECH.I-002N/22; consortium between Galenic Laboratory Olsztyn Ltd. and IAR&FR PAS in Olsztyn – coordinators: Prof. W. Wiczkowski, Asst. Prof. B. Fotschki).
  4. The Potential of the Combined Osmoconcentration-Lactic Fermentation Process in Shaping the Profile of Bioactive Components of New Onion Varieties Studied in an In Vivo Model (National Science Centre, Poland; project No. 2022/45/B/NZ9/00550; consortium between Lodz University of Technology and IAR&FR PAS in Olsztyn – main investigator: Prof. J. Juśkiewicz).
  5. Is Metabolic Effect of Copper Nanoparticles Reliant on Dietary Fibre with Different Physiological Function? (National Science Centre, Poland; project No. 2021/41/B/NZ9/01104; principal investigator: Prof. J. Juśkiewicz).
  6. Alleviation of Adverse Effects Associated with High-Fat Diet through Dietary Patterns Changes and/or Supplementation of Various Forms of Chromium (National Science Centre, Poland; project No. 2020/39/B/NZ9/00674; principal investigator: Prof. J. Juśkiewicz).
  7. Polyphenols from Raspberries and their Metabolites as Factors Regulating Mechanisms of Nonalcoholic Fatty Liver Disease (National Science Centre, Poland; project No. 2018/31/D/NZ9/02196, principal investigator: B. Fotschki, Ph.D.).
  8. Nutritional and Health Promoting Properties of Diets Supplemented with Seeds or Oils from Seeds of Some Plants (National Science Centre, Poland; project No. 2016/23/B/NZ9/01012, principal investigator: Assoc. Prof. A. Jurgoński).

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Team of Reproductive Pathology and Translational Medicine

Our research focuses on reproductive pathology and the immuno-endocrine regulation of the reproductive system and mammary gland. The results of these studies contribute to the development of new biotechnologies that support the fertility of domestic animals (horse, cow, pig) and humans.

We are interested in understanding the immuno-endocrine mechanisms that regulate the ovarian cycle and the development and progression of pregnancy in both physiological and pathological conditions. We study the processes and factors involved in oocyte maturation and embryo development. Recently, our group has started research on the involvement of changes in  membrane potential and its effect on the early stages of embryogenesis.

We are searching – at the transcriptome, proteome, and metabolome levels – new factors involved in the remodeling of the uterine endometrium during the ovarian cycle and pregnancy, as well as in the formation, function, and regression of the corpus luteum. We examine the involvement of the immune system and role of innervations and neuromediators in the pathogenesis of  ovarian, uterine and mammary gland disorders. We also explore the etiopathogenesis of embryo mortality, analyzing pathomechanisms at both the molecular and cellular levels.

Our analyses are based on analysis of receptor-ligand interactions, mechanisms of action of hormones, cytokines, neurotransmitters, and other bioactive substances on cellular and organ function.

In addition to the basic research, we are also conducting applied research to develop new strategies for preventing infertility in animals and humans. We are developing innovative biotechnological procedures, such as oocyte and ovarian tissue cryopreservation techniques.

Furthermore, we are seeking new diagnostic and therapeutic solutions for diseases of the reproductive system and mammary gland, based on novel biomarkers and drug targets. We are particularly interested in alternative methods to antibiotics for treating inflammatory conditions of the uterus and mammary gland.

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Physiology and Toxicology

We study how natural environmental factors and its contamination affect physiological processes related to reproduction and the central regulation of the functioning of animal and human organisms.

We focus on local physiological processes occurring in the female reproductive system, the central nervous system, and the brain barriers in response to environmental factors (e.g. circadian cycle), biologically active food components, mycotoxins, and endocrine-active compounds.

Our research concerns the endocrine and molecular mechanisms involved in the regulation of the ovarian cycle and pregnancy. We also analyze the molecular mechanisms responsible for the remodeling of the endometrial lining during early pregnancy.

We also investigate intracellular mechanisms of action of steroid hormones, neuropeptides, and other natural biologically active substances, as well as industrial environmental pollutants (e.g., xenobiotics, pesticides, herbicides, industrial waste). We examine how they regulate the functions of reproductive system cells, the hypothalamus, and brain barriers.

Additionally, we analyze the impact of environmental factors such as changing day length and circadian rhythm on the functioning of the hypothalamus and brain barriers.

Our research is conducted using animal research models (cow, sheep, pig, rat; in vivo), as well as animal and human tissue cultures and primary cells and cell lines (in vitro).

The studies conducted by our team are basic research; however, their results may have practical applications, including in the treatment of reproductive issues in humans and animals and in the prevention of neurodegenerative diseases.

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Physiology and Toxicology

The aim of the research conducted in the Department is to explain the role of the local physiological regulations in the control of female reproductive organ and their neuroendocrine mechanisms. The subject of the study is:

in central nervous system:

  1. influence of environmental factors (photoperiod and phyto- and xenoestrogens) on function of the brain barriers regulating the access of substances to the brain,
  2. the retrograde transfer of neurohormones and local destination transfer of male pheromones in the perihypophyseal vascular complex located at base of the brain,
  3. humoral pathway for the action of male pheromone on reproductive processes in females;

in reproductive organs:

  1. regulative effects of the retrograde transfer of steroid ovarian hormones,
  2. the role of uterine blood supply in the regulation of animal estrous cycle,
  3. retrograde transfer (to the uterus) and local destination transfer (to the ovary and oviduct) of uterine prostaglandins and their influence on uterine and ovarian function.

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Research papers

2025

  1. Akbari Nargesi, Erfan; Falahatkar, Bahram; Żarski, Daniel orcid. Semen quality, seminal plasma characteristics, and their relationships in the Anzali lagoon migratory population of Caspian roach (Rutilus caspicus) in the breeding season. Journal of Utilization and Cultivation of Aquatics 2025, 14(1): 253-269 (10.22069/japu.2024.22337.1862).

  2. Aleksandrowicz, Róża orcid; Strączkowski, Marek orcid. RXRs expression in skeletal muscle in relationship with insulin sensitivity in normal-weight and obese volunteers. Journal of Diabetes and Metabolic Disorders 2025, 24(1): art. no 51 (1-6) (10.1007/s40200-024-01546-9).

  3. Amaral, Ana; Sadowska, Agnieszka orcid; Cerveira-Pinto, Marta; Kordowitzki, Paweł; Skarżyński, Dariusz J. orcid; Ferreira-Dias Graça; Szóstek-Mioduchowska, Anna Z. orcid Ovarian steroids modulate mRNA expression of ECM associated genes and collagen deposition induced by TGF β1 in equine endometrium in vitro. Scientific Reports 2025, 15: art. no 538 (1-12) (10.1038/s41598-024-84250-1).

  4. Asnaashari, Solmaz; Jahanban-Esfahlan, Ali; Amarowicz, Ryszard orcid. Harnessing essential oils for acetylcholinesterase inhibition: a literature review. Phytotherapy Research 2025, 39(6): 2915-2988 (10.1002/ptr.8512).

  5. Babu, Reshma S. orcid; Jurgoński, Adam orcid. Nutritional and Metabolic Consequences of Camelina Seed Oil Compared to Flaxseed Oil in a Rat Diet. Molecules 2025, 30(13): art. no 2738 (1-13) (10.3390/molecules30132738).

  6. Balkrishna, Acharya; Rai, Priyanka; Verma, Rashmi; Rohela, Akansha; Kumar, Ashwani; Arya, Vedpriya; Khan, Nazam; Amarowicz, Ryszard orcid; Kumar, Dinesh; Verma, Rachna. Mechanistic insight into anti-inflammatory potential, phytochemistry and ethnomedicinal status of Ilex species: a review. Phytochemistry Reviews 2025, 24: 845-877 (10.1007/s11101-024-09968-2).

  7. Bogusławska, Joanna; Rakhmetullina, Aizhan; Grzanka, Małgorzata; Białas, Alex; Rybicka, Beata; Życka-Krzesińska, Joanna; Molcan, Tomasz orcid; Zielenkiewicz, Piotr; Pączek, Leszek; Piekiełko-Witkowska, Agnieszka. miR395e from Manihot esculenta Decreases Expression of PD-L1 in Renal Cancer: A Preliminary Study. Genes 2025, 16(3): art. no 293 (1-11) (10.3390/genes16030293 ).

  8. Cava-Cami, Berta; Galvão, António M. orcid; Van Ranst, Heidi; Stocker, William A.; Harrison, Craig A.; Smitz, Johan; De Vos, Michel; Kelsey, Gavin; Anckaert, Ellen. Pro-cumulin addition in a biphasic in vitro oocyte maturation system modulates human oocyte and cumulus cell transcriptomes. Molecular Human Reproduction 2025, 31(1): art. no gaaf001 (1-15) (10.1093/molehr/gaaf001).

  9. Cejko, Beata I. orcid; Sławomir, Krejszeff; Cejko, Agata A.; Dryl, Katarzyna orcid . Evaluating sperm characteristics from stripping and testicular extraction in northern pike (Esox lucius) with a focus on stability during storage. Animal Reproduction Science 2025, 247: art. no 107789 (1-12) (10.1016/j.anireprosci.2025.107789).

  10. Cydzik, Michał; Demska-Zakęś, Krystyna; Szczepkowski, Mirosław; Szczepkowska, Bożena; Sarosiek, Beata orcid; Blitek, Michał; Kowalski, Aleksy; Kowalski, Radosław K. orcid The influence of sperm activation methods and oocyte collection on the reproductive effects of northern pike (Esox lucius). Animals 2025, 15(1): art. no 8 (1-15) (10.3390/ani15010008).

  11. Debernardis, Rossella orcid; Palińska-Żarska, Katarzyna; Judycka, Sylwia orcid; Panda, Abhipsa orcid; Jarmołowicz, Sylwia; Jastrzębski, Jan P.;Rocha de Almeida, Taina; Błażejewski, Maciej; Hliwa, Piotr; Krejszeff, Sławomir; Żarski, Daniel orcid. Does transcriptome of freshly hatched fish larvae describe past or predict future developmental trajectory?. Aquaculture 2025, 595(Part 1): art. no 741486 (1-15) (10.1016/j.aquaculture.2024.741486).

  12. Dietrich, Mariola A. orcid; Kodzik, Natalia orcid; Bakun, Magdalena; Szczepkowski, Mirosław; Ciereszko, Andrzej orcid. Phosphoproteomic profiling of Siberian sturgeon (Acipenser baerii Brandt, 1869) sperm: Insights into cryopreservation-induced changes with DMSO and methanol. Biology of Reproduction 2025, przyjęta do druku (10.1093/biolre/ioaf128).

  13. Drzewiecka, Ewa M. orcid; Liszewska, Ewa orcid; Kozłowski, Krzysztof; Ciereszko, Andrzej orcid; Słowińska, Mariola orcid. Research note: Reference genes selection for gene expression analyses in reproductive turkey (Meleagris gallopavo) with yellow semen syndrome. Poultry Science 2025, 104(6): art. no 105093 (1-5) (10.1016/j.psj.2025.105093).

  14. Drzewiecka, Ewa M. orcid; Molcan, Tomasz orcid; Sadowska, Agnieszka orcid; Piotrowska-Tomala, Katarzyna K. orcid; Słyszewska, Magda orcid; Ferreira-Dias, Graça M.; Skarżyński, Dariusz J. orcid; Szóstek-Mioduchowska, Anna Z. orcid The myometrial transcriptome changes in mares with endometrosis. Scientific Reports 2025, 15: art. no 3173 (1-17) (10.1038/s41598-025-86742-0).

  15. Drzewiecka, Ewa M. orcid; Szóstek-Mioduchowska, Anna Z. orcid; Wiśniewska, Joanna orcid; Liszewska, Ewa orcid; Słowińska, Mariola orcid. Research note: Turkey (Meleagris gallopavo) semen CD14+ macrophages – management, key features, and classification – a pilot study with optimized protocols. Poultry Science 2025, 104(9): art. no 105397 (1-6) (10.1016/j.psj.2025.105397).

  16. Franczak, Anita; Żmijewska, Agata; Drzewiecka, Ewa M. orcid; Kozłowska, Wiktoria; Wydorski, PaweŁ; Paukszto, Łukasz; Brevini, Tiziana L. Effect of electromagnetic field radiation on transcriptomic profile and DNA methylation level in pig conceptuses during the peri-implantation period. Scientific Reports 2025, 15: art. no 14025 (1-21) (10.1038/s41598-025-98918-9).

  17. Gospodarska, Emilia orcid; Ghosh Dastidar, Ranjini orcid; Jarosławska-Miszkiewicz, Julia orcid; Rybiński, Maciej orcid; Raczyk, Marianna orcid; Tokarczyk-Malesa, Kornelia; Romaszko, Jerzy; Carlberg, Carsten orcid. Transcriptomic profiling of immune modulation induced by vitamin D3 in the VitDPAS and VitDHiD cohort studies . Scientific Reports 2025, 15: art. no 17334 (1-13) (10.1038/s41598-025-02495-w).

  18. Grzęda, Emilia; Gutkowska-Kawka, Dominika orcid; Matuszewska, Julia; Kilańczyk, Ewa; Kaczmarek, Monika orcid; Dylewski, Łukasz; Sliwowska, Joanna H. Maternal cafeteria diet adversely affects the reproductive parameters of rat offspring in a sex-specific manner. Reproductive Biology and Endocrinology 2025, 23(1): art. no 79 (1-15) (10.1186/s12958-025-01412-0).

  19. Jackowska, Agnieszka; Grabowska, Iwona orcid; Kurzątkowska-Adaszyńska, Katarzyna orcid. Electrochemical RNA-based aptasensor for neomycin detection in milk samples. Food Control 2025, 175: art. no 111257 (1-11) (10.1016/j.foodcont.2025.111257).

  20. Jana, Barbara orcid; Andronowska, Aneta orcid; Całka, Jarosław; Mówińska, Aleksandra orcid. Biosynthetic pathway for leukotrienes is stimulated by lipopolysaccharide and cytokines in pig endometrial stromal cells. Scientific Reports 2025, 15: art. no 2806 (1-11) (10.1038/s41598-025-86787-1).

  21. Janiak, Michał A. orcid; Gryn-Rynko, Anna; Sulewska, Katarzyna orcid; Amarowicz, Ryszard orcid; Penkacik, Kamila orcid; Graczyk, Radomir; Olszewska-Słonina, Dorota; Majewski, Michał S. Phenolic profiles and antioxidant activity of Morus alba L. infusions prepared from commercially available products and naturally collected leaves. Scientific Reports 2025, 15: art. no 13030 (1-12) (10.1038/s41598-025-97223-9).

  22. Jaworska, Joanna orcid; Tobolski, Dawid; Salem, Shebl E.; Kahler, Anne; Wocławek-Potocka, Izabela orcid; de Mestre, Amanda M. Single-cell atlas of the pregnant equine endometrium before and after implantation. Biology of Reproduction 2025, 112(3): 458-473 (10.1093/biolre/ioaf004).

  23. Kaur, Jasjit; Kaushik, Deepika; Kumar, Mukul; Babagil, Gülçin Emel; Amarowicz, Ryszard orcid; Proestos, Charalampos; Oz, Emel; Oz, Fatih; Esatbeyoglu, Tuba; Bordiga, Matteo. Comprehensive analysis and characterization of Mangifera indica L. leaf powder. Food Science and Nutrition 2025, 13(6): art. no e70083 (1-13) (10.1002/fsn3.70083).

  24. Krauze, Magdalena; Juśkiewicz, Jerzy orcid; Fotschki, Bartosz orcid; Pinkosz, Michalina; Ognik, Katarzyna. Hippocampus and jejunum biochemical parameters related to physiological ageing of neurons in rats fed diets with copper nanoparticles and different fiber types. Annals of Animal Science 2025, przyjęta do druku (10.2478/aoas-2024-0019).

  25. Krupa-Kozak, Urszula orcid; Płatosz, Natalia orcid; Bączek, Natalia orcid; Šimková, Kristýna; Starowicz, Małgorzata orcid. Increased content of bioactive compounds and health benefits of gluten-free sponge cakes resulting from enrichment with freeze-dried berry powders. Food Chemistry 2025, 472: art. no 142861 (1-12) (10.1016/j.foodchem.2025.142861).

  26. Künili, İbrahim Ender; Akdeniz, Vildan; Akpınar, Aslı; Öztürkoğlu Budak, Şebnem; Curiel, José Antonio; Guzel, Mustafa; Karagözlü, Cem; Kasikci, Muzeyyen Berkel; Caruana, Grech Perry Mario; Starowicz, Małgorzata orcid; Humblot, Christèle; Keyvan, Erhan; Chassard, Christophe; Pracer, Smilja; Vergères, Guy; Kesenkaş, Harun. Bioactive compounds in fermented foods: a systematic narrative review. Frontiers in Nutrition 2025, 12: art. no 1625816 (1-22) (10.3389/fnut.2025.1625816).

  27. Łagowska, Karolina; Jurgoński, Adam orcid; Mori, Mari; Yamori, Yukio; Murakami, Shigeru; Ito, Takashi; Toda, Toshiya; Pieczyńska-Zając, Joanna Maria; Bajerska, Joanna. Effects of dietary seaweed on obesity-related metabolic status: a systematic review and meta-analysis of randomized controlled trials. Nutrition Reviews 2025, 83(2): 113-130 (10.1093/nutrit/nuae042).

  28. Mahadeva, Manohara; Niestępski, Sebastian orcid; Kowacz, Magdalena orcid. Modifying membrane potential synchronously controls the somite’s formation periodicity and growth. Developmental Biology 2025, 517: 317-326 (10.1016/j.ydbio.2024.11.002).

  29. Mahé, Coline; Mówińska, Aleksandra orcid; Albrecht, Elke; Reynaud, Karine; Lavigne, Régis; Com, Emmanuelle; Pineau, Charles; Mermillod, Pascal; Saint-Dizier, Marie; Schoen, Jennifer. Laser capture proteomics reveals new candidates for sperm-interacting proteins in the bovine oviduct epithelium. Reproduction 2025, 170(2): art. no e240390 (1-15) (10.1530/REP-24-0390).

  30. Maissan, Parcival orcid; Carlberg, Carsten orcid. Circadian regulation of vitamin D target genes reveals a network shaped by individual responsiveness. Nutrients  2025, 17(7): art. no 1204 (1-15) (10.3390/nu17071204).

  31. Malecka-Baturo, Kamila orcid; Grabowska, Iwona orcid. Efficiency of electrochemical immuno- vs. apta(geno)sensors for multiple cancer biomarkers detection. Talanta 2025, 281: art. no 126870 (1-19) (10.1016/j.talanta.2024.126870).

  32. Marasek-Ciołakowska, Agnieszka; Machlańska, Aleksandra; Wiczkowski, Wiesław orcid; Szawara-Nowak, Dorota orcid; Lahuta, Lesław B.; Góraj-Koniarska, Justyna; Miyamoto, Kensuke; Ueda, Junichi; Saniewski, Marian; Horbowicz, Marcin. Effects of 1-N-Naphthylphthalamic acid on root and leaf development of Muscari armeniacum and the related metabolic and physiological features. International Journal of Molecular Sciences 2025, 26(13): art. no 6431 (1-18) (10.3390/ijms26136431).

  33. Marzec, Aleksandra; Cholewińska, Ewelina; Fotschki, Bartosz orcid; Juśkiewicz, Jerzy orcid; Stępniowska, Anna; Ognik, Katarzyna. Are the biodistribution and metabolic effects of copper nanoparticles dependent on differences in the physiological functions of dietary fibre?. Annals of Animal Science 2025, 25(1): 175-187 (10.2478/aoas-2024-0057).

  34. Mostek-Majewska, Agnieszka orcid; Bossowska-Nowicka, Magdalena; Słowińska, Mariola orcid; Ciereszko, Andrzej orcid. PRDX5 and PRDX6 translocation and oligomerization in bull sperm: a response to cryopreservation-induced oxidative stress. Cell Communication and Signaling 2025, 23: art. no 15 (1-16) (10.1186/s12964-024-02015-9).

  35. Mówińska, Aleksandra orcid; Rękawiecki, Robert orcid; Zając, Paulina orcid; Kowalik, Magdalena K. orcid Phoenixin-14 and its receptor GPR173 in the bovine endometrium: Expression and regulation during the estrous cycle and impact on secretory activity. Theriogenology 2025, 243: art. no 117456 (1-8) (10.1016/j.theriogenology.2025.117456).

  36. Myszczyński, Kamil; Szuszkiewicz, Joanna orcid; Krawczyński, Kamil orcid; Sikora, Małgorzata orcid; Romaniewicz, Marta orcid; Guzewska, Maria M. orcid; Zabielski, Piotr; Kaczmarek, Monika M. orcid In-depth analysis of miRNA binding sites reveals the complex response of uterine epithelium to miR-26a-5p and miR-125b-5p during early pregnancy. Molecular and Cellular Proteomics 2025, 24(1): art. no 100879 (1-16) (10.1016/j.mcpro.2024.100879).

  37. Narwal, Ekta; Choudhary, Jairam; Kumar, Manoj; Amarowicz, Ryszard orcid; Kumar, Sunil; Radha, -; Chandran, Deepak; Dhumal, Sangram; Singh, Surinder; Senapathy, Marisennayya; Rajalingam, Sureshkumar; Muthukumar, Muthamilselvan; Mekhemar, Mohamed. Botanicals as promising antimicrobial agents for enhancing oral health: a comprehensive review. Critical Reviews in Microbiology 2025, 51(1): 84-107 (10.1080/1040841X.2024.2321489).

  38. Ogrodowczyk, Anna M. orcid; Markiewicz, Lidia H. orcid; Szmatowicz, Beata orcid; Koźniewski, Bartłomiej; Wróblewska, Barbara orcid. Improved quality, sensory properties and nutraceutical potential of the fermented beverages fortified with freeze-dried berries and acacia honey. Food Chemistry 2025, 486: art. no 144469 (1-16) (10.1016/j.foodchem.2025.144469).

  39. Pardyak, Laura; Liszewska, Ewa orcid; Judycka, Sylwia orcid; Machcińska-Zielińska, Sylwia orcid; Karol, Halina orcid; Dietrich, Mariola A. orcid; Gojło, Ewa; Arent, Zbigniew; Bilińska, Barbara; Rusco, Giusy; Iaffaldano, Nicolaia; Ciereszko, Andrzej orcid; Słowińska, Mariola orcid. The effect of cryopreservation on the turkey (Meleagris gallopavo) semen proteome. Theriogenology 2025, 245: art. no 117473 (1-15) (10.1016/j.theriogenology.2025.117473).

  40. Piechowicz, Bartosz; Łaś, Sara; Łaś, Małgorzata; Łuc, Klaudia; Zaręba, Lech; Kobylarz, Damian; Kuliga, Aleksandra orcid; Grodzicki, Przemysław; Zienkiewicz, Andrzej; Romerowicz-Misielak, Maria. The effects of deltamethrin (a synthetic pyrethroid insecticide), an anionic surfactant alone, and a co-formulated mixture of these substances on the honeybee (Apis mellifera) temperature preference, CO2 emission, and expression of detoxification-related genes. Journal of Plant Protection Research 2025, 65(2): 187-199 (10.24425/jppr.2025.153285).

  41. Premathilaka, Chanaka; Feix, Anna Sophia; Papanikolaou, Konstantinos; Kjærup, Rikke; Andronowska, Aneta orcid; Kodithuwakku, Suranga; Fazeli, Alireza; Dalgaard, Tina S. Immunomodulatory effects of Ascardia galli excretory-secretory products, including extracellular vesicles on host immune cell function. Avian Pathology 2025, 4: 1-38 (10.1080/03079457.2025.2528838).

  42. Premathilaka, Chanaka; Kodithuwakku, Suranga; Midekessa, Getnet; Godakumara, Kasun; Ul Ain Reshi, Qurat; Andronowska, Aneta orcid; Orro, Toomas; Fazeli, Alireza. Bovine fecal extracellular vesicles: A novel noninvasive tool for understanding gut physiology and pathophysiology in calves. Journal of Dairy Science 2025, 108(4): 4116-4130 (10.3168/jds.2024-25920).

  43. Rahman, Nafis A.; Chrusciel, Marcin; Ponikwicka-Tyszko, Donata orcid; Pulawska-Moon, Kamila; Doroszko, Milena; Stelmaszewska, Joanna; Keuzer, Oliver J.; Rivero-Muller, Adolfo; Bernaczyk, Piotr; Zalewski, Grzegorz; Guo, Peilan; Toppari, Jorma; Li, Xiangdong; Ziecik, Adam J.; Wołczyński, Sławomir orcid; Huhtaniemi, Ilpo. Targeted destruction of follicle stimulating hormone receptor-positive cancer cells in vitro and in vivo by a lytic peptide Phor21-FSHβ conjugate. Molecular Medicine 2025, 31(1): art. no 224 (1-17) (10.1186/s10020-025-01292-5).

  44. Rahman, Nafis A.; Chrusciel, Marcin; Ponikwicka-Tyszko, Donata orcid; Puławska-Moon, Kamila; Stelmaszewska, Joanna; Doroszko, Milena; Kreuzer, Oliver J.; Rivero-Muller, Adolfo; Li, Xiangdong; Zięcik, Adam J. orcid; Wołczyński, Sławomir orcid; Huhtaniemi, Ilpo T. Hecate-FSHβ33-53C/S lytic peptide conjugate selectively kills targeted follicle stimulating hormone receptor (FSHR)-positive cancer cells. Biomedicine & Pharmacotherapy 2025, 186: art. no 118022 (1-10) (10.1016/j.biopha.2025.118022).

  45. Różaniecka-Zwolińska, Karolina; Cholewińska, Ewelina; Fotschki, Bartosz orcid; Juśkiewicz, Jerzy orcid; Ognik, Katarzyna. Manganese deficiency or dietary manganese(III) oxide nanoparticle supplementation: consequences for hematology, and intestinal and brain immunity in rats. Frontiers in Immunology 2025, 16: art. no 1528770 (1-10) (10.3389/fimmu.2025.1528770).

  46. Sana; Ahmad, Waqar; Anwar, Farooq; Ismail, Hammad; Farid, Mujahid; Ayub, Muhammad Adnan; Sumrra, Sajjad Hussain; Emenike, Chijioke; Starowicz, Małgorzata orcid; Zubair, Muhammad. Multifactorial evaluation of honey from pakistan: essential minerals, antioxidant potential, and toxic metal contamination with relevance to human health risk. Foods 2025, 14(14): art. no 2493 (1-23) (10.3390/foods14142493).

  47. Schiele, Phillip; Sada Japp, Alberto; Stark, Regina; Sattelberg, Joanna J.; Nikolaou, Christos; Kornhuber, Gereon; Abbasi, Parya; Ding, Nina; Rosnev, Stanislav; Meinke, Stefan; Mühle, Kerstin; Loyal, Lucie; Braun, Julian; Dingeldey, Manuela; Durlanik, Sibel; Matzmohr, Nadine; Ponikwicka-Tyszko, Donata orcid; Wołczyński, Sławomir orcid; Rahman,Nafis A.; Taniuchi, Ichiro; Schlickeiser, Stephan; Giesecke-Thiel, Claudia; Blankenstein, Thomas; Na, Il-Kang; Thiel, Andreas; Frentsch, Marco. CD8+ T cell-derived CD40L mediates non-canonical cytotoxicity in CD40-expressing cancer cells. Science Advances 2025, 11(21): art. no eadr9331 (-14) (10.1126/sciadv.adr9331).

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  49. Sołek, Przemysław; Różaniecka-Zwolińska, Karolina; Stępniowska, Anna; Ognik, Katarzyna; Juśkiewicz, Jerzy orcid; Fotschki, Bartosz orcid. Consequences of detary Manganese-based nanoparticles supplementation or deficiency on systemic health and gut metabolic dynamics in rats. Nanotechnology, Science and Applications 2025, 18: 19-34 (10.2147/NSA.S494533).

  50. Stryiński, Robert; Fiedorowicz, Ewa; Mateos, Jesús; Andronowska, Aneta orcid; Łopieńska-Biernat, Elżbieta; Carrera, Mónica. Exploring the exoproteome of the parasitic nematode Anisakis simplex (s. s.) and its impact on the human host – an in vitro cross-talk proteomic approach. Frontiers in Immunology 2025, 16: art. no 1509984 (1-18) (10.3389/fimmu.2025.1509984).

  51. Ścieszka, Sylwia; Piekarska-Radzik, Lidia; Klewicki, Robert; Sójka, Michał; Juśkiewicz, Jerzy orcid; Fotschki, Bartosz orcid; Klewicka, Elżbieta; Grzelak-Błaszczyk, Katarzyna. Spontaneously fermented Allium cepa L. as a source of lactic acid bacteria with probiotic potential. Scientific Reports 2025, 15: art. no 25970 (1-17) (10.1038/s41598-025-10037-7).

  52. Walewska, Edyta orcid; Hamada, Zahra; Pérez-García, Vicente; Galvão, António M. orcid Altered uterine leptin signalling in obese mothers: from impaired decidualisation to pregnancy complications. Reproduction 2025, 169: art. no e240319 (1-15) (10.1530/REP-24-0319).

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Publishing Unit

The Institute is the publisher of two international journals: Polish Journal of Food and Nutrition Sciences (since 1991) and Reproductive Biology (since 2001).

Polish Journal of Food and Nutrition Sciences is quarterly published in English. IT covers fundamental and applied research in food and nutrition sciences as well as disseminates the directions and results of Polish research works. It promotes an international scientific co-operation by publishing works of foreign authors. Scientific standard of Journal is constantly verified by recognized international and native scientists as well as by Ph.D, D.Sc. Magdalena Karamać – Editor –in-Chief and M.Sc. Joanna Molga – Secretary of the Editorial Office.

Reproductive Biology is published four times a year in English. It covers a wide spectrum of research from the filled of animal reproduction, including reproductive physiology, endocrinology, immunology, molecular and cellular biology, receptor studies, animal breeding, andrology, embryology, infertility, assisted reproduction and contraception. It publishes papers of foreign authors and promotes achievements of Polish research centers. Its Editorial Board consists of recognized specialist in the human and animal reproduction.  Dr. Renata Ciereszko is  currently the Editor-in-Chief of the journal.

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Metabolomics

Profile

The laboratory conducts research to determine the spectrum of metabolites present in organisms and tissues of plants or animals – metabolome. As a new tool to study the impact of diet consumed on the health status of man and society, metabolomics allows simultaneous analysis of a whole range of compounds present in raw materials and food products, and also after ingestion of metabolites in biological fluids of the body.

Food of plant origin contains thousands of phytochemicals – secondary metabolites of plants. Their content in a plant and consumed products is determined by several factors, including genetic factors, abiotic stress, technological processes and storage. Metabolomics is an indispensable tool for conducting targeted plant breeding, the optimization of biotechnological processes and storage of food in the aspect of the subsequent effects on the consumer’s body.

After ingestion most phytochemicals are absorbed, metabolized, distributed and excreted. As a result of complex processes of biotransformation, a number of metabolites are formed in the body, with many of these remaining unidentified. Ultimately, hundreds of metabolites possessing uncertain biological activity occur in biological fluids of the body and affect its homeostasis. Metabolomics enables tracking of metabolic pathways of these compounds, which consequently allows the inference about the impact of nutrition on the incidence of disorders.

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