Our research focuses on reproductive pathology and the immuno-endocrine regulation of the reproductive system and mammary gland. The results of these studies contribute to the development of new biotechnologies that support the fertility of domestic animals (horse, cow, pig) and humans.

We are interested in understanding the immuno-endocrine mechanisms that regulate the ovarian cycle and the development and progression of pregnancy in both physiological and pathological conditions. We study the processes and factors involved in oocyte maturation and embryo development. Recently, our group has started research on the involvement of changes in  membrane potential and its effect on the early stages of embryogenesis.

We are searching – at the transcriptome, proteome, and metabolome levels – new factors involved in the remodeling of the uterine endometrium during the ovarian cycle and pregnancy, as well as in the formation, function, and regression of the corpus luteum. We examine the involvement of the immune system and role of innervations and neuromediators in the pathogenesis of  ovarian, uterine and mammary gland disorders. We also explore the etiopathogenesis of embryo mortality, analyzing pathomechanisms at both the molecular and cellular levels.

Our analyses are based on analysis of receptor-ligand interactions, mechanisms of action of hormones, cytokines, neurotransmitters, and other bioactive substances on cellular and organ function.

In addition to the basic research, we are also conducting applied research to develop new strategies for preventing infertility in animals and humans. We are developing innovative biotechnological procedures, such as oocyte and ovarian tissue cryopreservation techniques.

Furthermore, we are seeking new diagnostic and therapeutic solutions for diseases of the reproductive system and mammary gland, based on novel biomarkers and drug targets. We are particularly interested in alternative methods to antibiotics for treating inflammatory conditions of the uterus and mammary gland.

We study how natural environmental factors and its contamination affect physiological processes related to reproduction and the central regulation of the functioning of animal and human organisms.

We focus on local physiological processes occurring in the female reproductive system, the central nervous system, and the brain barriers in response to environmental factors (e.g. circadian cycle), biologically active food components, mycotoxins, and endocrine-active compounds.

Our research concerns the endocrine and molecular mechanisms involved in the regulation of the ovarian cycle and pregnancy. We also analyze the molecular mechanisms responsible for the remodeling of the endometrial lining during early pregnancy.

We also investigate intracellular mechanisms of action of steroid hormones, neuropeptides, and other natural biologically active substances, as well as industrial environmental pollutants (e.g., xenobiotics, pesticides, herbicides, industrial waste). We examine how they regulate the functions of reproductive system cells, the hypothalamus, and brain barriers.

Additionally, we analyze the impact of environmental factors such as changing day length and circadian rhythm on the functioning of the hypothalamus and brain barriers.

Our research is conducted using animal research models (cow, sheep, pig, rat; in vivo), as well as animal and human tissue cultures and primary cells and cell lines (in vitro).

The studies conducted by our team are basic research; however, their results may have practical applications, including in the treatment of reproductive issues in humans and animals and in the prevention of neurodegenerative diseases.

Our interdisciplinary research focuses on wild animal conservation in the context of preserving biodiversity.

Our research is conducted in several areas.

The first is to expand the current knowledge about the mechanisms shaping the biodiversity of agro-ecosystems. We determine how environmental factors (e.g., stress or foraging base in the habitat) influence the condition of animals, as well as the quality of technological parameters and the content and bioavailability of biologically active components in the raw materials obtained from them.

To understand the changes occurring in the environment, we also study the interactions between epigenetic factors (epizootic, climatic, and toxicological) and the physiological processes in animals in their natural habitats. An important goal of our research is also to identify species-specific adaptations of animals to environmental changes along with their consequences for homeostasis (the ability of the organism to self-regulate biological processes).

We focus on implementing reproductive biotechnics as tools for diagnosing, controlling, and preserving biodiversity, as well as developing markers of reproductive potential.

The interdisciplinary nature of our team allows for the comprehensive use of research material in accordance with the principle of 6R (refuse, reduce, reuse, recover, recycle, rethink). We prioritize the effective use of animal tissues for both research and application purposes – e.g., in medical and veterinary therapies.

We also collaborate with economic stakeholders and the State Forests towards the development of feed additives, reproductive biotechnics, and meat products with valuable nutritional properties.