We study how natural environmental factors and its contamination affect physiological processes related to reproduction and the central regulation of the functioning of animal and human organisms.
We focus on local physiological processes occurring in the female reproductive system, the central nervous system, and the brain barriers in response to environmental factors (e.g. circadian cycle), biologically active food components, mycotoxins, and endocrine-active compounds.
Our research concerns the endocrine and molecular mechanisms involved in the regulation of the ovarian cycle and pregnancy. We also analyze the molecular mechanisms responsible for the remodeling of the endometrial lining during early pregnancy.
We also investigate intracellular mechanisms of action of steroid hormones, neuropeptides, and other natural biologically active substances, as well as industrial environmental pollutants (e.g., xenobiotics, pesticides, herbicides, industrial waste). We examine how they regulate the functions of reproductive system cells, the hypothalamus, and brain barriers.
Additionally, we analyze the impact of environmental factors such as changing day length and circadian rhythm on the functioning of the hypothalamus and brain barriers.
Our research is conducted using animal research models (cow, sheep, pig, rat; in vivo), as well as animal and human tissue cultures and primary cells and cell lines (in vitro).
The studies conducted by our team are basic research; however, their results may have practical applications, including in the treatment of reproductive issues in humans and animals and in the prevention of neurodegenerative diseases.
