The National Science Center (NCN) has announced the results of the Opus 22, Opus Lap, and Sonata 17 calls. Among the awarded projects are works by six scientists from our Institute.

A total of 116 projects from the Life Sciences (NZ) panel within the Opus 22 competition and 80 projects within the Sonata 17 competition qualified for funding by NCN. Among the approved applications are six projects carried out by scientists from our Institute.

OPUS is a funding opportunity intended for a wide range of applicants. The research proposal submitted under this scheme may include the purchase or construction of research equipment:

• Prof. Dr. Andrzej Ciereszko – Towards unraveling the role of carp cold acclimation protein 31 (Cap31) – a new important player in fish antimicrobial defense?

Budget: PLN 1,802,715

The project aims to obtain information on the hitherto undescribed Cap31 protein, including its structure, characteristics, localization, dynamics of changes during cold acclimation, and infectioń of fish with microbes. The research hypothesis is that Cap31 can modify single-stranded DNA and RNA of microorganisms whose expression depends on infectioń with microorganisms. Cap31 may also be an essential biomarker of fish welfare.

• Robert J. Rękawiecki Ph.D. – The role of the methylation of the progesterone receptor isoforms A and B promoters in the regulation of bovine corpus luteum function.

Budget: PLN 1,387,384

This project aims to expand the knowledge of how the methylation process works in the reproductive system. Learning about this regulation of corpus luteum function within the promoters of the A and B isoforms of the progesterone receptor may have important implications for understanding disorderś of pregnancy in cows and other species. Scientists will examine how these processes are regulated and whether they can be influenced.

• Daniel Żarski, Ph.D. – Exploration of the development, role, and functioning of circadian rhythm in early life stages of Perca fluviatilis.

Budget: PLN 700,365

The project will fill gaps in knowledge about the development and functioning of the biological clock and circadian rhythm in the early developmental stages of the perch. The research will examine whether the „sense of time” already appears in embryos or only in European perch larvae and how it changes during the fish’s development. The researchers will also examine to what extent a different photoperiod (period of exposure to light) from the natural one affects the circadian rhythm in the early developmental stages of perch. The results will provide valuable information for protecting freshwater ecosystems from the increasingly common anthropogenic light pollution.

The project is being carried out jointly with the Stanislaw Sakowicz Inland Fisheries Institute (IRŚ), led by Dr. Katarzyna Palińska-Żarska.

OPUS LAP allows researchers at all stages of their scientific careers to apply for funding for projects carried out in international cooperation under the Lead Agency Procedure track.

• Prof. Anna J. Korzekwa – Biotope influences genetic diversity, fitness traits, microbiome, and embryonic diapause in the European roe deer.

Budget: PLN 1,861,012

The aim of the project is to investigate the long-term influence of environmental factors on the biological processes and genetic diversity of ruminants. Using the European roe deer as a model species, scientists will evaluate the relationship between genetic diversity, epigenetic environmental mechanisms and ruminant health parameters. The research material in the project will be collected posthumously from roe deer from three ecotypes: forest, field and mosaic. Scientists will also check how the composition of the food consumed by deer affects the microflora of these animals.

The project is implemented in cooperation with the University of Primorska, Faculty of Mathematics, Natural Sciences and Information Technology under the supervision of Prof. Elena Buzan.

SONATA is a competition aimed at researchers with a doctoral degree, obtained from 2 to 7 years before the year of application. It is designed to support those embarking on their scientific careers to conduct innovative research.

• Dr. Agnieszka Mostek-Majewska – Potential use of peroxiredoxins to improve the quality of cryopreserved bull semen.

Budget: PLN 1,959,780

Semen cryopreservation is an important tool in artificial reproduction technologies in livestock farming. However, this process is accompanied by side effects that negatively affect the sperm motility, and disrupt the capacitation and fertilization process. The aim of Dr. Mostek’s project is to investigate the possibility of improving cryopreserved bull semen by the addition of enzymes from the peroxyredoxin group (PRDX), which will reduce the oxidative stress occurring during the freeze-thaw process, and thus maintain the redox balance in sperm.

• Dr. Anna Ogrodowczyk – The role of milk matrix lipids in programming the immunoreactivity of proteins derived from lactic acid bacteria.

Budget: PLN 1,799,500

The project aims to program selected strains of lactobacillus bacteria to produce proteins that can potentially mitigate food allergies. The study’s results may providé evidence of interactions between lactic acid bacteria proteins and the human immune system.

Total budget allocated for the implementation of the projects reaches over 9,5 mln zlotych.