Anna Szóstek-Mioduchowska, Ph.D., from our Institute, has received the first-degree award for outstanding scientific achievement presented in the form of a monothematic series of works constituting the basis for awarding the habilitation degree. Her research work is widely commented on and highly appreciated in the scientific community, resulting in numerous awards.
On April 14, 2022, the Annual Awards Committee meeting for 2021 was held. Polish Society of Veterinary Sciences. After considering the submitted applications, the Commission decided to award the first-degree prize to a scientist from the Department of Immunology and Reproductive Pathology. Anna Szóstek-Mioduchowska, Ph.D., was honored for her outstanding scientific achievement presented in the form of a monothematic series of papers: „The role of selected mediators of inflammatory response and lysophosphatidic acid in the development of endometriosis in mares”.
The performed studies describe the influence of inflammatory mediators released by immune cells (mainly macrophages) on processes connected with the development of endometriosis in mares. It is an active or inactive fibrotic process that develops around the glands of the endometrium and in the connective tissue stroma. It leads to excessive deposition of extracellular matrix (ECM) and activation of cells called fibroblasts.
These studies will help to understand the mechanisms underlying the pathogenesis of endometriosis, which in the future may contribute to the development of effective therapeutic strategies (also in humans for the treatment of endometriosis).
Another award in a scientific career
It is worth mentioning that this is another award for Szóstek-Mioduchowska for her research on the mechanisms of endometriosis in mares. The XVI Congress of the Polish Society of Veterinary Sciences „Omnia Autem Animalia Sunt” took place on November 26-27, 2021, where Szóstek-Mioduchowska was awarded for the highest scored oral presentation in the session on equine physiology and pathology. At the end of the year, she also received a distinction during the 5th edition of the Scientific Awards of the Olsztyn and Białystok Branches of the Polish Academy of Sciences.
Works constituting the basis for awarding the habilitation degree:
- Effect of transforming growth factor-β1 on α- smooth muscle actin and collagen expression in equine endometrial fibroblasts. Theriogenology 2019, 124:9-17.
- Effect of proinflammatory cytokines on endometrial collagen and metallopeptidase expression during the course of equine endometrosis. Cytokine 2019, 123:154767.
- Matrix metallopeptidase expression and modulation by transforming growth factor-β1 in equine endometrosis. Scientific Reports 2020, 10:1119.
- Prostaglandins effect on matrix metallopeptidase and collagen in mare endometrial fibroblasts. Theriogenology 2020, 153:74-84.
- Lysophosphatidic acid as a regulator of endometrial prostaglandin and connective tissue growth factor secretion during estrous cycle and endometrosis in the mare. BMC Veterinary Journal 2020, 16:343.