Institute of Animal Reproduction and Food Research, Olsztyn, Poland
Post-doctoral in an NCN project SONATA BIS 9 entitled „Maternal obesity and epigenetic and metabolic regulations during gametogenesis and early embryo development in mice: the specific role of leptin signalling”.
The Lab of Dr Antonio Galvao is recruiting an experienced computational biologist to integrate the research programme on ovarian function in mouse models for maternal obesity. The escalating epidemic of overweight and obesity is a major burden for our health systems. Obesity leads to long-term health problems, such as diabetes, cardiovascular disease or infertility. In the lab we use mouse models and/or in vitro systems of ovarian/follicular culture to study the impact of maternal obesity in ovarian function and oocyte biology. The project investigates particularly the impact of altered leptin signalling in the ovary, a major feature of obese mothers, on the establishment of oocyte epigenome and metabolic regulations in both gamete and surrounding granulosa cells throughout folliculogenesis. The present research programme benefits from the close collaboration with the Laboratory of Dr Gavin Kelsey, Babraham Institute, Cambridge, UK, a world leader in single cell transcriptome and methylome analysis. The appointed scientist will be responsible for undertaking the analysis of methylome, transcriptome and lipidome datasets generated within the programme.
This work will lead to important advances in our understanding of the impact of altered leptin signalling in oocyte epigenome establishment, profiling also metabolic and gene expression changes in granulosa cells and other underlying mechanisms.
Key areas of responsibility:
- quality control of NGS datasets,
- providing high-level support in bioinformatic analysis of genome-wide epigenomic datasets,
- integration and analysis of RNA-seq, BS-seq and other relevant datasets,
- application of bioinformatics methods to single-cell datasets,
- preparation of manuscripts, including sequence dataset submission to public repositories.
Person specification: Essential
- Ph.D. in Bioinformatics or Computational biology, or Ph.D. in a Molecular biology or related discipline with a strong Bioinformatics component,
- working knowledge of epigenomic and transcriptomic analyses,
- programming in some of the main languages used in Bioinformatics (in particular R, Python, Java),
- working understanding of statistics and statistical programming environments,
- able to understand and communicate in English to a level appropriate for the position,
- ability to work independently and as part of a team,
- excellent organisational skills, with good time management,
- excellent interpersonal skills with the ability to communicate with staff at all levels,
- proactive, motivated, showing initiative to move projects forward,
- ability to make independent decisions and solve routine problems.
The post is initially available for 24 months, with the salary range of 85 000 – 98 000 PLN / year (before taxes/brutto), based on experience. Applications will be accepted until 27th of February 2023 and interviews will be held soon after. Applications should be submitted to the e-mail address: email@example.com.
Documents to present with the application:
- Cover letter highlighting the suitability of the candidate to the post (max 2 pages),
- CV (max 6 pages),
- One contact reference (one of letters must be from the last supervisor/line manager).
For informal questions about the post please contact Dr Galvao (firstname.lastname@example.org).
In your CV, please include a consent clause for the processing of personal data in the recruitment process:
„I consent to the processing of my personal data contained in the application documents by the Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences in Olsztyn, 10-748 Olsztyn, ul. Tuwima 10, in order to carry out the recruitment process and publishing the full results of the competition on the Institute’s website”.
- The administrator of personal data processed as part of the recruitment process is the Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences in Olsztyn, 10-748 Olsztyn, ul. Tuwima 10, phone no. 89 523 46 86, e-mail: email@example.com.
- Contact with the personal data protection officer is possible at the above-mentioned address.
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