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Achievements LPR


Main achievements of the Department concern the explanation of physiological mechanisms of local and central regulations of the reproductive processes in females.

In central nervous system:

  • It was demonstrated the influence of the photoperiod on the expression of transthyretin (protein transporter of thyroid hormones across the barrier blood-cerebrospinal fluid) in ovine choroid plexus. For the first time, the concentration of thyroid hormones in ovine cerebrospinal fluid was estimated. The relationship between the concentration of these hormones in blood and cerebrospinal fluid nether in breeding season nor in anestrus was found.
  • It was demonstrated the influence of the photoperid on the expression of short form of leptin receptors (OB-Ra) in porcine choroid plexus.
  • It was discovered retrograde transfer of neurohormones (LH-RH, oxytocin, beta-endorfin) and destination transfer of steroid pheromones to the blood supplying the brain and hypophysis in the perihypophyseal vascular complex (carotid rete mirabile – venous cavernous sinus).
  • It was revealed the humoral pathway for local transfer of boar pheromone – androstenol from the nasal mucosa to the blood supplying the brain and hypophysis and selective accumulation of androstenol in the hypophysis and certain structures of the hypothalamus and limbic system. We demonstrated that intramuscular application of androstenol accelerated the attainment of sexual maturation and influenced hormonal regulation of the periestrous period in gilts with experimental hypoosmia. The humoral pathway for boar pheromone action include their influence on the function of the superficial veins of the nose and face, regulating blood flow from the nasal cavity to the venous cavernous sinus of the perihypophyseal vascular complex.

In reproductive organs:

  • It was demonstrated that local transfer of steroid ovarian hormones from the ovarian blood and lymph to the ovarian artery elevated their concentrations in blood supplying the ovary by 80-150% and supplying the uterus and oviduct by 22-60%.
  • It was demonstrated a short regulatory loop of positive feedback between progesterone being retrograde transferred and its own secretion; positive effect of this transfer on activin A and androstenedione secretion, and negative effect on estradiol secretion.
  • It was demonstrated that in the mechanism of the retrograde and local destination transfer of uterine prostaglandins F2alfa and E2 a fundamental role fulfilled lymphatic vessels and small blood vessels of the mesometrium. Local transfer of prostaglandins is involved to the regulation of secretory function of the ovary as well as the blood supply to the reproductive organ and by this way it is one of main regulator of their cyclic function.
  • It was demonstrated the sensitivity of uterine and ovarian blood vessels to prostaglandins; in case of E2 it was dependent on the phase of the estrous cycle and pregnancy, and F2alfa – independent on the stage of reproductive processes.
  • It was demonstrated that infusion of oxytocin into the uterine artery on day 17 of the estrous cycle produced contractions of the uterus accompanied with immediate increase in PGF2alfa concentration in ovarian venous blood. Thus, pulsate elevation of PGF2alfa after luteolysis, when the endometrium undergoes of cyclic remodeling and the expression of PGF2alfa synthase is reduced, results from their excretion, together with uterine venous blood and lymph.

Original theory on mechanisms regulating the estrous cycle, with special regard of physiological ishemia of the endometrium effect on course of animal estrous cycle was published.