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Prophylaxis of Metabolic Diseases

Our research is focused on the pathogenesis of insulin resistance In subjects at risk of developing type 2 diabetes. The study groups include subjects with positive family history of type 2 diabetes and subjects with overweight or obesity. Lean healthy subjects without family history of diabetes serve as a control group.

We utilize methods for in vivo measurement of insulin sensitivity and glucose and lipid oxidation. They are combined with the precise assessment of body composition, with a special focus on visceral fat content. We perform isolation of peripheral blood mononuclear cells and the biopsies of subcutaneous abdominal adipose tissue and vastus lateralis muscle, with a subsequent analysis of tissue gene expression with RT-PCR.

We conduct interventional studies, with the aim to assess the effect of the combination of low-calorie diet with the selected diet supplements on visceral adipose tissue content and insulin sensitivity in obese subjects with normal glucose tolerance.

From February 2011 the Department participates in the project “School Promoting Health”, conducted in primary and secondary schools.